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A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

Authors

  • Anandkumar Nandakumar,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Roman Truckenmüller,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Maqsood Ahmed,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Febriyani Damanik,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Diogo Reis Santos,

    1. Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4200-072 Porto, Portugal
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  • Nils Auffermann,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Jan de Boer,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Pamela Habibovic,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Clemens van Blitterswijk,

    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
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  • Lorenzo Moroni

    Corresponding author
    1. Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
    • Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands.

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Abstract

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Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.

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