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Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging

Authors

  • Tianjiao Ji,

    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
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  • Ying Zhao,

    Corresponding author
    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
    • Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China.
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  • Jing Wang,

    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
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  • Xin Zheng,

    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
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  • Yanhua Tian,

    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
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  • Yuliang Zhao,

    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
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  • Guangjun Nie

    Corresponding author
    1. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China
    • Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China.
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Abstract

original image

Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.

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