Artificial DNA tethering azobenzene through a backbone-inserted glycerol via an ether bond is synthesized. The stabilization effect of the hybrid duplex with a native complementary strand of DNA for R-glycerol-inserted DNA is demonstrated even when the molar ratio of azobenzene to nucleotide is 1:2. The half-lives of tens of hours for glycerol-tethered cis-azobenzene and the rapid and highly efficient trans-to-cis photoisomerization in the hybrid DNA duplex at room temperature render the manipulation of DNA nanodevices and functionalities by photoregulation in a green system possible.
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