Aptamer-Directed Synthesis of Multifunctional Lanthanide-Doped Porous Nanoprobes for Targeted Imaging and Drug Delivery

Authors

  • Li Zhou,

    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    Search for more papers by this author
  • Zhenhua Li,

    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    Search for more papers by this author
  • Enguo Ju,

    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    Search for more papers by this author
  • Zhen Liu,

    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    Search for more papers by this author
  • Jinsong Ren,

    Corresponding author
    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    • Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625.

    Search for more papers by this author
  • Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    • Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625.

    Search for more papers by this author

Abstract

Multifunctional lanthanide-doped porous nanoparticles are prepared via a facile one-step solvothermal route by employing aptamers as the biotemplate. The nanoparticles feature excellent aqueous dispersibility and biospecific properties and could work as effective nanoprobes for targeted imaging and drug delivery. With aptamer being in principle available for any kind of target, this synthetic strategy may open the door to a new generation of nanoprobes for bioapplications such as time-resolved biodetection, multimode bioimaging/biolabeling, and targeted cancer therapy.

Ancillary