Get access

Light-Induced Generation of Singlet Oxygen by Naked Gold Nanoparticles and its Implications to Cancer Cell Phototherapy

Authors

  • George Pasparakis

    Corresponding author
    1. Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), PO Box 1527, 711 10, Heraklion, Crete, Greece
    Current affiliation:
    1. University College London, School of Pharmacy, 29–39 Brunswick Square, London, WC1N 1AX, UK
    • Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology Hellas (FORTH), PO Box 1527, 711 10, Heraklion, Crete, Greece.

    Search for more papers by this author

Abstract

original image

Generation of singlet oxygen by direct irradiation of naked gold nanoparticles is observed using either continuous wave or pulsed laser sources. The underlying mechanism involves plasmon- and hot-electron-mediated reaction pathways and 1O2 seems to significantly amplify the overall death rates during photothermal treatment of cancer cell lines in vitro.

Get access to the full text of this article

Ancillary