SEARCH

SEARCH BY CITATION

Keywords:

  • intracellular microenvironment responsive;
  • multiple-stage gene delivery;
  • controlled gene release;
  • nucleus uptake
Thumbnail image of graphical abstract

A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.