Drug Delivery: Shuttle-Mediated Nanoparticle Delivery to the Blood–Brain Barrier (Small 6/2013)

Authors

  • Daniela Guarnieri,

    1. Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy
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  • Annarita Falanga,

    1. Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples “Federico II”, Via Mezzocannone 16, 80134, Napoli, Italy
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  • Ornella Muscetti,

    1. Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy
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  • Rossella Tarallo,

    1. Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples “Federico II”, Via Mezzocannone 16, 80134, Napoli, Italy
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  • Sabato Fusco,

    1. Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy
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  • Massimiliano Galdiero,

    1. Department of Experimental Medicine - II University of Naples, Via De Crecchio 7, 80138, Napoli, Italy
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  • Stefania Galdiero,

    Corresponding author
    1. Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples “Federico II”, Via Mezzocannone 16, 80134, Napoli, Italy
    • Stefania Galdiero, Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples “Federico II”, Via Mezzocannone 16, 80134, Napoli, Italy.

      Paolo A. Netti, Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy

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  • Paolo A. Netti

    Corresponding author
    1. Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy
    • Stefania Galdiero, Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples “Federico II”, Via Mezzocannone 16, 80134, Napoli, Italy.

      Paolo A. Netti, Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli and Interdisciplinary Research Centre on Biomaterials (CRIB) University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy

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Abstract

original image

Viruses are formidable micromachines able to overcome potent physiological barriers and to penetrate deep inside our tissues. Following a bioinspired approach, S. Galdiero, P. A. Netti, and co-workers created a novel class of nanoparticles able to cross the vascular brain endothelium membrane, obtained by decorating their surface with the membranotropic gH625 peptide sequence derived from the glycoprotein gH of Herpes simplex type 1 virus envelope. This promising strategy, described on page 853, paves the way for designing delivery systems to improve administration of therapeutical compounds to the brain.

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