Carbon Nanotubes: Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway (Small 9–10/2013)

Authors

  • Li Meng,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Rui Chen,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Aihua Jiang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Liming Wang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China
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  • Peng Wang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Chen-zhong Li,

    1. Nanobioengineering/Bioelectronics Lab, Department of Biomedical Engineering, Florida International University, Miami, USA
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  • Ru Bai,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Yuliang Zhao,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    2. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China
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  • Herman Autrup,

    1. Department of Public Health, Aarhus University, Aarhus, Denmark
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  • Chunying Chen

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
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Abstract

original image

The front cover image for this special issue was provided by C. Chen and co-workers. CNTs show good biocompatibility, and can be used to modulate neurite outgrowth in culture and in vivo. Positive effects such as promoting regeneration and differentiation can be initiated by up-regulating cellular uptake and exocytosis. On page 1786 it is shown that shorter carboxyl-terminated multiwall carbon nanotubes (MWCNTs) demonstrate higher cellular uptake by PC12 cells and more obvious exocytosis compared to longer ones. Incubation of PC12 cells with carboxylated MWCNTs does not affect cellular morphology or viability at lower concentrations.

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