Mesoporous Silicon: Short and Long Term, In Vitro and In Vivo Correlations of Cellular and Tissue Responses to Mesoporous Silicon Nanovectors (Small 9–10/2013)

Authors

  • Jonathan O. Martinez,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX USA
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  • Christian Boada,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Escuela de Medicina y Ciencias de la Salud, TEC de Monterrery, Monterrey, Mexico
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  • Iman K. Yazdi,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Department of Biomedical Engineering, University of Houston, Houston, TX, USA
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  • Michael Evangelopoulos,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
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  • Brandon S. Brown,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX USA
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  • Xuewu Liu,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
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  • Mauro Ferrari,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
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  • Ennio Tasciotti

    Corresponding author
    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    • Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.
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Abstract

original image

Current assessment of the toxicity associated with nanocarriers provides poor insight into their true impact on cell function and cell fate. This pseudo-colored scanning electron microscopy image from E. Tasciotti and co-workers shows a nanoporous silicon particle in the process of being engulfed by murine macrophages. The particle induces a response in the macrophage, which triggers filopodic tentacles to extend and capture the nanocarrier to begin phagocytosis. Alternative methods are proposed on page 1722 to effectively study the influences of nanovectors on biological systems.

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