Quantum Dots: The Influence on Cell Cycle and Cell Division by Various Cadmium-Containing Quantum Dots (Small 14/2013)

Authors

  • Yuexian Liu,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Peng Wang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Yue Wang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Zhening Zhu,

    1. Laboratory of Nanomaterials, National Center for Nanoscience and Technology of China Beijing 100190, China
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  • Fang Lao,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Xuefeng Liu,

    1. Laboratory of Nanomaterials, National Center for Nanoscience and Technology of China Beijing 100190, China
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  • Wenshu Cong,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Chunying Chen,

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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  • Yan Gao,

    Corresponding author
    1. Laboratory of Nanomaterials, National Center for Nanoscience and Technology of China Beijing 100190, China
    • Laboratory of Nanomaterials, National Center for Nanoscience and Technology of China Beijing 100190, China.
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  • Ying Liu

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
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Abstract

original image

C. Chen, Y. Gao, Y. Liu, and co-workers compare the influence of the chemical composition and surface modification of seven cadmium-based quantum dots (QDs) on living cells. These parameters determine the amount of Cd2+ released within the cell, and on page 2440 they find that CdTe@ZnS shelled QDs show much lower cytotoxicity than naked ones with similar surface modifications. Moreover, positively charged QDs are more toxic than negatively charged ones. Both positively and negatively charged QDs without ZnS coatings lead to multipolar spindles, misaligned chromosomes, and G2/M checkpoint failures.

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