Lab-on-Chip: Acute On-Chip HIV Detection Through Label-Free Electrical Sensing of Viral Nano-Lysate (Small 15/2013)

Authors

  • Hadi Shafiee,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Muntasir Jahangir,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Fatih Inci,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • ShuQi Wang,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Remington B. M. Willenbrecht,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Francoise F. Giguel,

    1. Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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  • Athe M. N. Tsibris,

    1. Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Daniel R. Kuritzkes,

    1. Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Utkan Demirci

    Corresponding author
    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    2. Division of Biomedical Engineering, Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    • Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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Abstract

original image

On page 2553, U. Demirci and co-workers address the need for clinical HIV-I detection at the acute stage, where antibodies are present in very low concentrations. Their fast and extremely affordable portable diagnostic tool allows on-chip virus detection without the need for any labeling steps. Through impedance analysis, the device can sense the unique electrical signature of the viral nano-lysates. This means that the tool is also highly selective, could be easily extended for use in detecting other infectious diseases, and could even be adapted to detect multiple diseases at the same time.

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