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DNA Detection: A Molecular Beacon-Based Signal-Off Surface-Enhanced Raman Scattering Strategy for Highly Sensitive, Reproducible, and Multiplexed DNA Detection (Small 15/2013)

Authors

  • Xinpan Wei,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Shao Su,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
    2. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, PR China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Yuanyuan Guo,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
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  • Xiangxu Jiang,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
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  • Yiling Zhong,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
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  • Yuanyuan Su,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
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  • Chunhai Fan,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, PR China
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  • Shuit-Tong Lee,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
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  • Yao He

    Corresponding author
    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China
    • Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China.
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Abstract

original image

A molecular beacon-based signal-off SERS strategy is developed by Y. He and co-workers on page 2493, who employ stem–loop oligonucleotides as novel capture and reporter probes. This signal-off strategy exhibits excellent sensitivity, specificity, reproducibility, and adequate multiplexing capacity, opening up exciting opportunities towards practical SERS-relevant sensing applications. The cover image shows that DNA strands are readily detected via observing an effective signal switch from an ‘on’ (left) to an ‘off’ (right) state.

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