Drug Delivery: Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells (Small 16/2013)

Authors

  • Cuie Chen,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Li Zhou,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Jie Geng,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Jinsong Ren,

    Corresponding author
    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
    • State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
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  • Xiaogang Qu

    Corresponding author
    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
    • State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
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Abstract

original image

A light-operated vehicle for targeted intracellular drug delivery has been constructed by J. Ren, X. Qu, and co-workers using photosensitizer-incorporated G-quadruplex DNAcapped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates reactive oxygen species, causing the DNA capping to be cleaved and allowing the cargo (drugs) to be released. This platform, described in detail on page 2793, makes it possible to develop a drug-carrier system for a synergistic combination of chemotherapy and photodynamic therapy for the treatment of cancer with a high spatial/temporal control.

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