Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF4:Yb,Tm)/CaF2 Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation (Small 19/2013)

Authors

  • Jie Shen,

    1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Guanying Chen,

    1. Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Tymish Y. Ohulchanskyy,

    1. Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
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  • Samuel J. Kesseli,

    1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
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  • Steven Buchholz,

    1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
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  • Zhipeng Li,

    1. Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina, 27599, USA
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  • Paras N. Prasad,

    1. Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    2. Department of Chemistry, Korea University, Seoul 136-701, Korea
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  • Gang Han

    Corresponding author
    1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    • Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
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Abstract

original image

Upconversion nanoparticles (UCNPs) can convert tissue-penetrable nearinfrared light into UV emission, making them promising as transducers for photoactivation in biology. However, the choice of the UV emitting UCNPs is limited and their NIR-to-UV efficiency is low. G. Han and co-workers have addressed this issue by developing a family of CaF2-coated UCNPs with tunable UV enhancement. As reported on page 3213, such design outperforms known optimal UCNPs and in situ realtime live-cell photoactivation is recorded for the first time with such nanoparticles. This result is a potential game changer in photoactivation in living systems and a new tool for other biophotonic applications.

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