Nanowires: Fibroblasts Cultured on Nanowires Exhibit Low Motility, Impaired Cell Division, and DNA Damage (Small 23/2013)

Authors

  • Henrik Persson,

    1. Division of Solid State Physics, Lund University, Box 118, 22100 Lund, Sweden
    2. The Nanometer Structure Consortium, Lund University, Box 118, 22100 Lund, Sweden
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  • Carsten Købler,

    1. Center for Electron Nanoscopy, Technical University of Denmark, Ørsteds Plads 345E, 2800 Kongens Lyngby, Denmark
    2. Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads 345E, 2800 Kongens Lyngby, Denmark
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  • Kristian Mølhave,

    1. Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads 345E, 2800 Kongens Lyngby, Denmark
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  • Lars Samuelson,

    1. Division of Solid State Physics, Lund University, Box 118, 22100 Lund, Sweden
    2. The Nanometer Structure Consortium, Lund University, Box 118, 22100 Lund, Sweden
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  • Jonas O. Tegenfeldt,

    1. Division of Solid State Physics, Lund University, Box 118, 22100 Lund, Sweden
    2. The Nanometer Structure Consortium, Lund University, Box 118, 22100 Lund, Sweden
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  • Stina Oredsson,

    1. The Nanometer Structure Consortium, Lund University, Box 118, 22100 Lund, Sweden
    2. Department of Biology, Lund University, Sölvegatan 37, 223 62 Lund, Sweden
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  • Christelle N. Prinz

    Corresponding author
    1. Division of Solid State Physics, Lund University, Box 118, 22100 Lund, Sweden
    2. The Nanometer Structure Consortium, Lund University, Box 118, 22100 Lund, Sweden
    3. Neuronano Research Center, Lund University, Sölvegatan 19, 221 84 Lund, Sweden
    • Division of Solid State Physics, Lund University, Box 118, 22100 Lund, Sweden.

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Abstract

original image

Mouse fibroblasts cultured on 7-μm-long vertical nanowires are reported on page 4006 by C. N. Prinz and co-workers. Culturing cells on this kind of substrate interferes greatly with cell function, causing the cells to develop into widely different morphologies. The cells' division is impaired, in many cases leading to large multinuclear cells. Cell motility is also impeded, something the large cluster surrounded by unoccupied substrate bears witness to for this otherwise motile cell line.

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