Nano-objects are generated through 3D confined supramolecular assembly, followed by a sequential disintegration by rupturing the hydrogen bonding. The shape of the nano-objects is tunable, ranging from nano-disc, nano-cup, to nano-toroid. The nano-objects are pHresponsive. As Z. Z. Yang, J. T. Zhu, and co-workers describe on page 4099, functional materials, for example inorganic nanoparticles, can be easily incorporated into the surface to extend both the composition and microstructure of the nano-objects, which is important in drug delivery, targeting, catalysis, and imaging.