Quantum Dots: Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide (Small 24/2013)

Authors

  • Ming-Zhen Zhang,

    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
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  • Yong Yu,

    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
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  • Rong-Na Yu,

    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
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  • Min Wan,

    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
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  • Rong-Ying Zhang,

    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
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  • Yuan-Di Zhao

    Corresponding author
    1. Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China
    • Britton Chance Center for Biomedical Photonics at, Wuhan National Laboratory for Optoelectronics–Hubei, Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology Wuhan 430074, PR China.

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Abstract

original image

Y.-D. Zhao and co-workers report on page 4183 a new multifunctional quantum dot (QD) probe by coupling anti-hFR-α antisense oligonucleotide (AS-ODN) and targeted peptide p160 with QDs through biotin-streptavidin interaction for realtime tracking of AS-ODN and regulation of hFR-α in MCF-7 breast cancer cells. The QD probes enter into the cytoplasm effectively through receptor-mediated endocytosis, and after endosomal release, AS-ODN combines with its target mRNA and blocks hFR-α protein translation. This multifunctional QD probe not only achieves gene silencing in a cell-specific manner but also achieves real-time tracking during AS-ODN intracellular delivery.

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