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Keywords:

  • DNA structures;
  • DNA origami;
  • self-assembly;
  • hydrophobic effect
Thumbnail image of graphical abstract

Amphiphilic DNA origami is prepared by dressing multiple hydrophobic molecules on a rectangular single layer DNA origami, which is then folded or coupled in sandwich-like structures with two outer DNA origami layer and one inner hydrophobic molecules layer. The preference to form different kinds of structures could be tailored by rational design of DNA origami.