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Preparation and Self-folding of Amphiphilic DNA Origami

Authors

  • Chao Zhou,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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  • Dianming Wang,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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  • Yuanchen Dong,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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  • Ling Xin,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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  • Yawei Sun,

    1. Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum, No 66, Changjiang West Road, Qingdao Economic & Technical Development Zone, Qingdao, China
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  • Zhongqiang Yang,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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  • Dongsheng Liu

    Corresponding author
    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
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Abstract

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Amphiphilic DNA origami is prepared by dressing multiple hydrophobic molecules on a rectangular single layer DNA origami, which is then folded or coupled in sandwich-like structures with two outer DNA origami layer and one inner hydrophobic molecules layer. The preference to form different kinds of structures could be tailored by rational design of DNA origami.

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