Graphene Oxide: Photothermally Controlled Gene Delivery by Reduced Graphene Oxide–Polyethylenimine Nanocomposite (Small 1/2014)

Authors

  • Hyunwoo Kim,

    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-dong, Pohang, 790-784, Korea
    2. Center for Self-assembly and Complexity, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yusung-gu, Daejeon, 305-811, Korea
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  • Won Jong Kim

    Corresponding author
    1. Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-dong, Pohang, 790-784, Korea
    2. Center for Self-assembly and Complexity, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yusung-gu, Daejeon, 305-811, Korea
    • Department of Chemistry, Pohang University of Science and Technology, San 31, Hyoja-dong, Pohang, 790-784, Korea.

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Abstract

original image

An external-stimuli-triggered and spatially and temporally controlled gene delivery vehicle is constructed by H. Kim and W. J. Kim using a functionalized reduced graphene oxide (rGO)-based nanocomposite. Upon light irradiation, the vehicle generates local heat, causing the accelearated endosomal escape of polyplexes. This platform, described in detail on page 117, makes it possible to develop a photothermally controlled gene carrier with maximized therapeutic efficacy and high spatial/temporal control.

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