Carbon Nanotubes with High Bone-Tissue Compatibility and Bone-Formation Acceleration Effects (pages 240–246)
Yuki Usui, Kaoru Aoki, Nobuyo Narita, Narumichi Murakami, Isao Nakamura, Koichi Nakamura, Norio Ishigaki, Hiroshi Yamazaki, Hiroshi Horiuchi, Hiroyuki Kato, Seiichi Taruta, Yoong Ahm Kim, Morinobu Endo and Naoto Saito
Article first published online: 18 JAN 2008 | DOI: 10.1002/smll.200700670
Carbon nanotubes instead of crutches! It is found that multi-walled carbon nanotubes (CNTs) adjoining bone induce little local inflammatory reaction, show high bone-tissue compatibility, permit bone repair, become integrated into new bone (see figure), and accelerate bone formation stimulated by the recombinant human bone morphogenetic protein-2. This study provides an initial basis for use of CNTs in biomaterials placed adjacent to bone, including the promotion of bone regeneration.