Particle Size, Surface Coating, and PEGylation Influence the Biodistribution of Quantum Dots in Living Mice (pages 126–134)
Meike L. Schipper, Gopal Iyer, Ai Leen Koh, Zhen Cheng, Yuval Ebenstein, Assaf Aharoni, Shay Keren, Laurent A. Bentolila, Jianquing Li, Jianghong Rao, Xiaoyuan Chen, Uri Banin, Anna M. Wu, Robert Sinclair, Shimon Weiss and Sanjiv S. Gambhir
Article first published online: 2 DEC 2008 | DOI: 10.1002/smll.200800003
The living image: Quantitative biodistribution of near-infrared-emitting quantum dots (QDs) is studied in mice by micro positron emission tomography. PEGylation (PEG = polyethylene glycol) and peptide coating slow QD uptake into liver, spleen, and bone. Small peptide-coated QDs are in part renally excreted (see picture; < indicates bladder uptake).