Drug delivery: Logic-Embedded Vectors for Intracellular Partitioning, Endosomal Escape, and Exocytosis of Nanoparticles (Small 23/2010) (page 2690)
Rita E. Serda, Aaron Mack, Anne L. van de Ven, Silvia Ferrati, Kenneth Dunner Jr., Biana Godin, Ciro Chiappini, Matthew Landry, Louis Brousseau, Xuewu Liu, Andrew J. Bean and Mauro Ferrari
Article first published online: 3 DEC 2010 | DOI: 10.1002/smll.201090085
Cell-derived vectors containing nanoparticles represent a means for cell-to-cell communication, biobarrier crossing, and dissemination of nanoparticle-encapsulated signals. The frontispiece image shows a pseudocolored transmission electron microscopy image with a membrane-enclosed vesicle containing iron oxide nanoparticles. These nanoparticle-loaded vectors were expelled from the cell following cellular internalization of logic-embedded vectors; that is, vectors that direct their own cellular and intracellular fate based on particle properties, such as size and surface chemistry. Other cellular destinations include the lysosome and cytoplasm. For more information, please read the Full Paper “Logic-Embedded Vectors for Intracellular Partitioning, Endosomal Escape, and Exocytosis of Nanoparticles” by R. E. Serda and co-workers, beginning on page 2690.