Small

Cover image for Vol. 6 Issue 12

June 21, 2010

Volume 6, Issue 12

Pages 1260–1352

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. Drug delivery: Cellular Association and Assembly of a Multistage Delivery System Small 12/2010

      Rita E. Serda, Aaron Mack, Merlyn Pulikkathara, Ana Maria Zaske, Ciro Chiappini, Jean R. Fakhoury, Douglas Webb, Biana Godin, Jodie L. Conyers, Xue W. Liu, James A. Bankson and Mauro Ferrari

      Version of Record online: 9 JUN 2010 | DOI: 10.1002/smll.201090037

      Thumbnail image of graphical abstract

      The cover image shows a pseudo-colored scanning electron microscopy image of a macrophage with two adherent discoidal porous silicon microparticles. Filopodia extends from the cell surface to initiate cellular uptake of the microparticles by phagocytosis. The oxidized silicon microparticle has a negative surface charge and a diameter of 3.2 µm. Aminosilyation of the silicon surface introduces free amines and a positive surface charge. The pore openings are approximately 50 nm in diameter and can be tuned to accommodate diverse cargo such as iron oxide nanoparticles for imaging and drug-encapsulated polymeric micelles or liposomes for therapeutic applications. The surface of the microparticle is readily functionalized with targeting ligands to direct surface adhesion and cellular uptake. For more information, please read the Full Paper “Cellular Association and Assembly of a Multistage Delivery System” by R. E. Serda, M. Ferrari, et al., beginning on page 1329.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. Fluorescence microscopy: Fluorescence microscopy: Nanoisland-Based Random Activation of Fluorescence for Visualizing Endocytotic Internalization of Adenovirus Small 12/2010

      Kyujung Kim, Joung-Woo Choi, Kyungjae Ma, Rimi Lee, Kyung-Hwa Yoo, Chae-Ok Yun and Donghyun Kim

      Version of Record online: 9 JUN 2010 | DOI: 10.1002/smll.201090038

      Thumbnail image of graphical abstract

      The cover image shows the imaging of adenovirus particles during cellular endocytosis on silver nanoislands. Surface-plasmon-enhanced random activation of locally amplified hot spots is triggered between nanoislands and excites the molecular-fluorescence-tagged adenovirus. The process allows for the resolution of extremely fine events below the diffraction limit as the nanoislands can be made to create hot spots small enough to spatially distinguish molecular events on the nanometer scale. Also, nanoislands can be chemically synthesized over a large area for mass production, so they may be highly important in a practical sense as a commercially viable super-resolution-imaging platform. Dramatically enhanced resolution is experimentally confirmed with fluorescent nanobeads, which is further applied to image the transport of an adenovirus across a live cell membrane. For more information, please read the Communication “Nanoisland-Based Random Activation of Fluorescence for Visualizing Endocytotic Internalization of Adenovirus” by C.-O. Yun, D. Kim, et al., beginning on page 1293.

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. Contents: Small 12/2010 (pages 1260–1263)

      Version of Record online: 9 JUN 2010 | DOI: 10.1002/smll.201090039

  4. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. Conductivity imaging

      Visualization of the Electrical Conductivity of Freestanding Nanowires (pages 1264–1267)

      Dirk H. Weber, André Beyer, Berthold Völkel and Armin Gölzhäuser

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000404

      Thumbnail image of graphical abstract

      Conductivity imaging is demonstrated for the first time. It allows extraction of the electrical conductivity of nanoscale objects from one image, as demonstrated for low-energy electron point source microscopy images of ZnO nanowires.

    2. Quantum dots

      Record-Low Inhomogeneous Broadening of Site-Controlled Quantum Dots for Nanophotonics (pages 1268–1272)

      Arun Mohan, Pascal Gallo, Marco Felici, Benjamin Dwir, Alok Rudra, Jerome Faist and Eli Kapon

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000341

      Thumbnail image of graphical abstract

      Large arrays of dense, site-controlled InGaAs/GaAs quantum dots (QDs) are grown by organometallic chemical vapor deposition in an ordered pattern of tetrahedral recesses (pyramids). These QDs exhibit a low inhomogeneous broadening (≈1 meV), large s–p separation (>50 meV), and efficient single-photon emission.

    3. Gold nanoparticles

      Preparation of Stable Maleimide-Functionalized Au Nanoparticles and Their Use in Counting Surface Ligands (pages 1273–1278)

      E. Oh, K. Susumu, J. B. Blanco-Canosa, I. L. Medintz, P. E. Dawson and H. Mattoussi

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000279

      Thumbnail image of graphical abstract

      A modular ligand made of poly(ethylene glycol) appended with a thioctic acid anchoring group at one end and a maleimide at the other is synthesized and used to prepare maleimide-functionalized gold nanoparticles (AuNPs). This design allows effective conjugation of AuNPs to peptide-dye via maleimide–thiol coupling. By tuning the fraction of maleimides per NP the number of surface ligands per AuNP can be estimated.

    4. Carbon nanotubes

      Prevention of Sn and Pb Crystallization in a Confined Nanospace (pages 1279–1282)

      Keita Kobayashi, Kazu Suenaga, Takeshi Saito and Sumio Iijima

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000265

      Thumbnail image of graphical abstract

      Sn, Pb, Ag, and Au are encapsulated within carbon nanotubes (CNTs) by capillary action. From high-resolution transmission electron microscopy imaging of the obtained materials, it is found that although Ag and Au crystallize within CNTs, Sn and Pb are in a pseudoliquid phase. The results suggest that a confined nanospace prevents crystal growth of metals having a low melting point.

    5. Photonic crystals

      Gallium Arsenide Infiltration of Nanoporous Multilayers: A Route to High-Dielectric-Contrast One-Dimensional Photonic Crystals (pages 1283–1287)

      Olalla Sánchez-Sobrado, Kevin Thomas, Ian Povey, Martyn E. Pemble and Hernán Míguez

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.200902190

      Thumbnail image of graphical abstract

      Periodic multilayers of wide photonic bandgap and high reflectance in the visible and near infrared regions are fabricated. Optical properties show that reflectance intensities close to 90% are reached for stacks of only six layers, as well as gap-to-midgap ratios of 50%. The optical response of the hybrid ensemble can be accurately tuned through the number of infiltration cycles performed.

    6. DNA architecture

      pH-Toggled DNA Architectures: Reversible Assembly of Three-Way Junctions into Extended 1D Architectures Through A-Motif Formation (pages 1288–1292)

      Sonali Saha, Dhiraj Bhatia and Yamuna Krishnan

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000330

      Thumbnail image of graphical abstract

      A three-way junction (3WJ) carrying A-motif-forming overhangs is shown to reversibly assemble into extended 1D nanoarchitectures and disassemble completely into a 3WJ by changing environmental pH. The topology of the 3WJ in the 1D architecture is confirmed by gold-nanoparticle immobilization followed by transmission electron microscopy.

    7. Fluorescence microscopy

      Nanoisland-Based Random Activation of Fluorescence for Visualizing Endocytotic Internalization of Adenovirus (pages 1293–1299)

      Kyujung Kim, Joung-Woo Choi, Kyungjae Ma, Rimi Lee, Kyung-Hwa Yoo, Chae-Ok Yun and Donghyun Kim

      Version of Record online: 31 MAY 2010 | DOI: 10.1002/smll.201000058

      Thumbnail image of graphical abstract

      Super-resolution imaging is performed on metallic nanoislands by plasmonic-based activation of random near-field hot spots. Nanoislands can be synthesized to create small hot spots that spatially distinguish molecular events on the nanometer scale. Enhanced resolution is experimentally confirmed with fluorescent nanobeads, and is extended to imaging the transport of an adenovirus across a live cell membrane.

    8. Microreactors

      Bubble Microreactors Triggered by an Alternating Magnetic Field as Diagnostic and Therapeutic Delivery Devices (pages 1300–1305)

      Fang Yang, Ping Chen, Wen He, Ning Gu, Xizhi Zhang, Kun Fang, Yu Zhang, JianFei Sun and Jiayi Tong

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000173

      Thumbnail image of graphical abstract

      Microcontainers with embedded superparamagnetic nanoparticles can be changed into bubble microreactors upon treatment with an alternating magnetic field, which acts as a remote trigger for the release of encapsulated material. Exchange of an arginine solution inside and H2O2 solution outside the microcontainers generates NO gas. The microstructure combines ultrasound diagnostic and NO therapeutic functionalities.

    9. Microfluidics

      Microfluidic Rheometer for Characterization of Protein Unfolding and Aggregation in Microflows (pages 1306–1310)

      Sungyoung Choi and Je-Kyun Park

      Version of Record online: 11 MAY 2010 | DOI: 10.1002/smll.201000210

      Thumbnail image of graphical abstract

      The balance between a sample and reference flow with a common pressure drop enables simple and accurate measurement of fluid viscosity without standard pressure gauges and complicate theoretical calculations. The microfluidic rheometer measures minute changes in a rheological property of bovine serum albumin by chemical and thermal denaturation.

  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. Carbon nanotubes

      Diameter- and Metallicity-Selective Enrichment of Single-Walled Carbon Nanotubes Using Polymethacrylates with Pendant Aromatic Functional Groups (pages 1311–1320)

      Xiaoyong Pan, Lain-Jong Li and Mary B. Chan-Park

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.200902415

      Thumbnail image of graphical abstract

      Single-walled nanotubes (SWNTs) synthesized by the CoMoCAT process are dispersed in dimethylforamide solution of poly(2-naphthylmethacrylate) (PNMA). The polymer backbone assists SWNT solvation whilst the large pendant aromatic structures have strong affinity to the metallic SWNTs. After centrifugation, the SWNTs are separated according to their electronic properties (metallic versus semiconducting) with high efficiency.

    2. Protein folding

      Nanoparticle-Induced Folding and Fibril Formation of Coiled-Coil-Based Model Peptides (pages 1321–1328)

      Sara C. Wagner, Meike Roskamp, Manjula Pallerla, Raheleh Rezaei Araghi, Sabine Schlecht and Beate Koksch

      Version of Record online: 31 MAY 2010 | DOI: 10.1002/smll.200902067

      Thumbnail image of graphical abstract

      Protein misfolding induced by nanoparticles is explored for naturally occurring proteins. The capacity of nanoscale objects to induce aggregation is apparently related to the protein sequence. The role of the primary structure involved in this process is systematically addressed by means of model peptides.

    3. Drug delivery

      Cellular Association and Assembly of a Multistage Delivery System (pages 1329–1340)

      Rita E. Serda, Aaron Mack, Merlyn Pulikkathara, Ana Maria Zaske, Ciro Chiappini, Jean R. Fakhoury, Douglas Webb, Biana Godin, Jodie L. Conyers, Xue W. Liu, James A. Bankson and Mauro Ferrari

      Version of Record online: 31 MAY 2010 | DOI: 10.1002/smll.201000126

      Thumbnail image of graphical abstract

      The retention of superparamagnetic iron oxide nanoparticles (SPIONs) in a porous silicon matrix is enhanced by aminosilylation of the loaded matrix with 3-aminopropyltriethoxysilane. Cellular uptake of the drug-delivery system and release of nanoparticles from the porous matrix are demonstrated.

    4. Hybrid nanoparticles

      Nematic-like Organization of Magnetic Mesogen-Hybridized Nanoparticles (pages 1341–1346)

      Arnaud Demortière, Saïwan Buathong, Benoît P. Pichon, Pierre Panissod, Daniel Guillon, Sylvie Bégin-Colin and Bertrand Donnio

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000285

      Thumbnail image of graphical abstract

      Induction of a fluid nematic-like phase, close to room temperature, is achieved in superparamagnetic iron oxide nanoparticles by surface hybridization with liquid-crystalline-promoting cyanobiphenyl-based ligands. Modularity in the self-organization and modification of the magnetocrystalline anisotropy energy of the covalent hybrids is allowed by this route.

    5. DNA structures

      DNA Minicircles Connected via G-Quadruplex Interaction Modules (pages 1347–1352)

      Diana P. N. Gonçalves, Thorsten L. Schmidt, Martin B. Koeppel and Alexander Heckel

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/smll.201000318

      Thumbnail image of graphical abstract

      G-quadruplex interaction modules are used as DNA glue to recruit and connect DNA minicircles. The minicircles are equipped with G-rich appendixes that can hybridize into quadruplexes in the presence of salts. The formation of homodimers, multimers, and of a topologically interlocked construct (catenane) is observed. Atomic force microscopy is used to visualize the G-nanoconstructs.

  6. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Contents
    5. Communications
    6. Full Papers
    7. Corrigendum
    1. You have free access to this content
      Cellular Association and Assembly of a Multistage Delivery System

      Rita E. Serda, Aaron Mack, Merlyn Pulikkathara, Ana Maria Zaske, Ciro Chiappini, Jean Fakhoury, Douglas Webb, Biana Godin, Jodie L. Conyers, Xue Wu Liu, James A. Bankson and Mauro Ferrari

      Version of Record online: 13 JUL 2010 | DOI: 10.1002/smll.201001027

      This article corrects:

      Cellular Association and Assembly of a Multistage Delivery System

      Vol. 6, Issue 12, 1329–1340, Version of Record online: 31 MAY 2010

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