Polyhydroxy Fullerenes for Non-Invasive Cancer Imaging and Therapy (pages 2236–2241)
Vijay Krishna, Amit Singh, Parvesh Sharma, Nobutaka Iwakuma, Qiang Wang, Qizhi Zhang, Jacquelyn Knapik, Huabei Jiang, Stephen R. Grobmyer, Ben Koopman and Brij Moudgil
Version of Record online: 3 SEP 2010 | DOI: 10.1002/smll.201000847
The novel optical properties of polyhydroxy fullerenes (PHF)—which are water-soluble, biodegradable and antioxidant—are applied for imaging and therapy of cancer. Tumors injected with PHF are imaged with photoacoustic tomography (PAT) and photothermally treated with near-infrared (NIR) laser. Tumor size decreases up to 72% within two hours of treatment, with only a blister visible after 20 hours.