Preclinical Evaluation of Raman Nanoparticle Biodistribution for their Potential Use in Clinical Endoscopy Imaging (pages 2232–2240)
Cristina L. Zavaleta, Keith B. Hartman, Zheng Miao, Michelle L. James, Paul Kempen, Avnesh S. Thakor, Carsten H. Nielsen, Robert Sinclair, Zhen Cheng and Sanjiv S. Gambhir
Article first published online: 24 MAY 2011 | DOI: 10.1002/smll.201002317
The biodistribution of gold Raman nanoparticles is evaluated after either intravenous (IV) or intrarectal (IR) administration in mice by radiolabeling them with 64Cu and imaging them using microPET. Results show localized accumulation in the colon followed by the rapid excretion of nanoparticles after IR injection with no appreciable uptake in any other organ. However, after IV injection, the results show immediate and continuous accumulation in several organs (i.e., liver, spleen).