Biosensors: Cancer Prognostics by Direct Detection of p53-Antibodies on Gold Surfaces by Impedance Measurements (Small 13/2012) (page 1962)
Elisabet Prats-Alfonso, Xavier Sisquella, Nadia Zine, Gemma Gabriel, Anton Guimerà, F. Javier del Campo, Rosa Villa, Adam H. Eisenberg, Milan Mrksich, Abdelhamid Errachid, Jordi Aguiló and Fernando Albericio
Article first published online: 4 JUL 2012 | DOI: 10.1002/smll.201290073
The cover image shows the detection of an antibody by its epitope immobilized through a self-assembled monolayer on a gold surface. The detection is made possible by impedance measurements. The light dots and flashes represent the electrical conductivity through the gold surface, where two different molecules are presented: the blocking molecules to avoid non-specific adsorption and the reactive epitopes. It is observed that the epitopes can be in different configurations to mimic the induced-fit approach, which is carried out by the proximity of the epitope to the reactive site of the antibody. For more information, please read the Full Paper “Cancer Prognostics by Direct Detection of p53-Antibodies on Gold Surfaces by Impedance Measurements” by E. Prats-Alfonso, F. Albericio, and co-workers, beginning on page 2106. Image credit: Gemma Gabriel and Elisabet Prats-Alfonso.