Merging High Doxorubicin Loading with Pronounced Magnetic Response and Bio-repellent Properties in Hybrid Drug Nanocarriers (pages 2381–2393)
Aristides Bakandritsos, Aristeidis Papagiannopoulos, Eleni N. Anagnostou, Konstantinos Avgoustakis, Radek Zboril, Stergios Pispas, Jiri Tucek, Vasyl Ryukhtin, Nikolaos Bouropoulos, Argiris Kolokithas-Ntoukas, Theodore A. Steriotis, Uwe Keiderling and Frank Winnefeld
Article first published online: 2 MAY 2012 | DOI: 10.1002/smll.201102525
Hybrid drug nanocarriers simultaneously exhibit bio-repellent properties, pronounced magnetic response, high loading capacity of the potent anticancer drug doxorubicin, in a manner that has not been attained before. The nanocarriers are based on a magnetic core and a two-layer bi-functional polymeric corona constituted from a polycarboxylate backbone and poly(ethylene glycol) branches.