Targeted Delivery of siRNA-Generating DNA Nanocassettes Using Multifunctional Nanoparticles (pages 1964–1973)
Young-Seok Cho, Gee Young Lee, Hari Krishna Sajja, Weiping Qian, Zehong Cao, Weiling He, Prasanthi Karna, Xiaoyuan Chen, Hui Mao, Y. Andrew Wang and Lily Yang
Article first published online: 6 JAN 2013 | DOI: 10.1002/smll.201201973
A multifunctional siRNA delivery nanoparticle platform that combines the imaging capability of the nanoparticles with urokinase plasminogen activator receptor-targeted delivery of siRNA-expressing DNA nanocassettes is developed. The ability to express siRNA from multiple nanocassettes conjugated to each nanoparticle following receptor-mediated internalization enhances the effect of gene silencing in tumor cells and in an animal tumor model.