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Cover image for Vol. 9 Issue 12

June 24, 2013

Volume 9, Issue 12

Pages 2025–2198

  1. Cover Picture

    1. Top of page
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    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
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    10. Full Papers
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      Networks: Supramolecular Nanofiber Webs in Nonwoven Scaffolds as Potential Filter Media (Small 12/2013) (page 2025)

      Holger Misslitz, Klaus Kreger and Hans-Werner Schmidt

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370066

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      Typically, polymer micro- and nanofibers are prepared by top-down approaches such as meltblowing or electrospinning. In contrast, H.-W. Schmidt and co-workers demonstrate on page 2053 a bottom-up approach via the self-assembly of small molecules to supramolecular nanofibers. This approach can form supramolecular nanofiber webs within a scaffold in situ. The remarkable intrinsic stability of the supramolecular nanofibers in combination with their good adhesion on the polymer scaffold result in microfiber/nanofiber composites, which are stable under typical air filtration conditions.

  2. Inside Front Cover

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
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    10. Full Papers
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      Fuel Cells: Bulk Metallic Glass Micro Fuel Cell (Small 12/2013) (page 2026)

      Ryan C. Sekol, Golden Kumar, Marcelo Carmo, Forrest Gittleson, Nathan Hardesty-Dyck, Sundeep Mukherjee, Jan Schroers and André D. Taylor

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370067

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      The first all-bulk metallic glass (BMG) micro fuel cell is designed by A. D. Taylor and co-workers, consisting of Pt-based BMG electrodes and Zr-based BMG endplates. BMGs are amorphous metal alloys readily formed into a variety of shapes and sizes. The Pt–BMG electrode with high catalytic activity takes advantage of multi-length scale thermoplastic forming to produce nanowires supported on a disc with 110 μm pores. Zr–BMG has superior corrosion resistance and conductivity beyond silicon, stainless steel, and graphite. On page 2081, this fuel cell is demonstrated for the first time as a flow field current collector.

  3. Masthead

    1. Top of page
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    3. Inside Front Cover
    4. Masthead
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    8. Communications
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      Masthead: (Small 12/2013)

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370068

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
    9. Frontispiece
    10. Full Papers
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      Contents: (Small 12/2013) (pages 2027–2033)

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370069

  5. Concepts

    1. Top of page
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    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
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    10. Full Papers
    1. Nanoparticles for Gene Delivery (pages 2034–2044)

      Huayu Tian, Jie Chen and Xuesi Chen

      Version of Record online: 30 APR 2013 | DOI: 10.1002/smll.201202485

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      General concepts in the development of nanoparticle-based carriers for gene delivery systems are summarized. This concept highlights the current status and possible future directions of gene delivery, with a particular emphasis on the clinical application of multifunctional nanocarriers on the combination of such properties as biodegradability, targetability, transfection ability, and stimuli sensitivity.

  6. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
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    10. Full Papers
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      Nanoparticles: Trapping and Photoacoustic Detection of CTCs at the Single Cell per Milliliter Level with Magneto-Optical Coupled Nanoparticles (Small 12/2013) (page 2045)

      Xiaoge Hu, Chen-Wei Wei, Jinjun Xia, Ivan Pelivanov, Matthew O'Donnell and Xiaohu Gao

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370070

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      Multifunctional nanoparticles with integrated magnetic, optical, and targeting properties enable simultaneous trapping and ultrasensitive detection of rare circulating tumor cells in blood vessels. On page 2046, photoacoustic imaging shows how the nanoprobes detect the cells at the single-cell-per-milliliter level, capturing two thirds of the labeled cells in just one pass. Compared to conventional in vitro assays, this technology has the potential to interrogate large sample volumes in a reasonable procedure time.

  7. Communications

    1. Top of page
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    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
    9. Frontispiece
    10. Full Papers
    1. Trapping and Photoacoustic Detection of CTCs at the Single Cell per Milliliter Level with Magneto-Optical Coupled Nanoparticles (pages 2046–2052)

      Xiaoge Hu, Chen-Wei Wei, Jinjun Xia, Ivan Pelivanov, Matthew O'Donnell and Xiaohu Gao

      Version of Record online: 30 NOV 2012 | DOI: 10.1002/smll.201202085

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      Multifunctional nanoparticles with integrated magnetic, optical, and targeting properties allow simultaneous trapping and detection of rare circulating tumor cells.

    2. Supramolecular Nanofiber Webs in Nonwoven Scaffolds as Potential Filter Media (pages 2053–2058)

      Holger Misslitz, Klaus Kreger and Hans-Werner Schmidt

      Version of Record online: 4 DEC 2012 | DOI: 10.1002/smll.201202334

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      Microfiber–nanofiber composites are prepared by in situ formation of supramolecular nanofiber webs based on 1,3,5-benzenetricarboxamides in polymer nonwoven scaffolds. The supramolecular nanofibers are strongly fixed to nonwoven microfibers. These composites are sufficiently stable to be suited for air filtration applications.

    3. DNA-Mediated Self-Assembly of Single-Walled Carbon Nanotubes into Nanorings (pages 2059–2063)

      Ali Yasin Sonay and Mustafa Culha

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/smll.201202804

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      Assembly into higher-order structures is very important to fully benefit from the extraordinary properties of nanomaterials. SWCNTs are assembled into nanorings using DNA hybridization. The oligonucleotides are covalently attached to the SWCNTs and an oligonucleotide complementary to the oligonucleotides covalently bound to SWCNTs is used to bring assemble them by hybridization.

    4. Electrochemical Synthesis of Transparent, Amorphous, C60-Rich, Photoactive, and Low-Doped Film with an Interconnected Structure (pages 2064–2068)

      Mao Li, Shinsuke Ishihara, Kei Ohkubo, Meiyong Liao, Qingmin Ji, Cheng Gu, Yuyu Pan, Xiangfen Jiang, Misaho Akada, Jonathan P. Hill, Takashi Nakanishi, Yuguang Ma, Yusuke Yamauchi, Shunichi Fukuzumi and Katsuhiko Ariga

      Version of Record online: 29 JAN 2013 | DOI: 10.1002/smll.201202680

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      An electrochemical synthesis is developed through quantitative electrochemical reaction of N-alkylcarbazole leading to a novel class of structurally interconnected high-C60 content (60 wt%) polymer films with negligible doping and intrinsic physicochemical properties of pure C60. This strategy allows preparation of previously unavailable low-doped fullerene-containing non-conjugated polymers and broadens the potential applications of electrochemical synthesis for controlled polymer film structures.

    5. Density-Controlled Synthesis of Uniform ZnO Nanowires: Wide-Range Tunability and Growth Regime Transition (pages 2069–2075)

      Dong Lai Guo, Li Huey Tan, Zhi Peng Wei, Hongyu Chen and Tom Wu

      Version of Record online: 29 JAN 2013 | DOI: 10.1002/smll.201201369

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      Monolayers of polymer-encapsulated Au nanoparticles with controlled density are obtained via a facile solution-based method by modulating the inter-particle repulsion and using empty polymer micelles as spacers. These Au nanoparticles are then used to catalyze the vapor transport growth of metal oxide nanowires, where distinct density-dependent growth regimes are identified.

    6. Visible Photoresponse of Single-Layer Graphene Decorated with TiO2 Nanoparticles (pages 2076–2080)

      Kaihong Zheng, Fanben Meng, Lin Jiang, Qingyu Yan, Huey Hoon Hng and Xiaodong Chen

      Version of Record online: 18 FEB 2013 | DOI: 10.1002/smll.201202885

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      A simple method to fabricate a visible light-detectable hybrid nanodevice based on TiO2 nanoparticles and pristine graphene, ideally combining the advantages of both, is demonstrated. High photosensitivity of the hybrid device under visible and UV light irradiation paves the way for its application as a broad wavelength photodetector.

    7. Bulk Metallic Glass Micro Fuel Cell (pages 2081–2085)

      Ryan C. Sekol, Golden Kumar, Marcelo Carmo, Forrest Gittleson, Nathan Hardesty-Dyck, Sundeep Mukherjee, Jan Schroers and André D. Taylor

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/smll.201201647

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      A bulk metallic glass (BMG) micro fuel cell displays advantages over traditional micro fuel cell designs in terms of performance and fabrication. The BMG gas flow fields are durable and shock and corrosion resistant, and the Pt-BMG catalytic layers (including Pt-BMG nanowires) are promising candidates for use in micro fuel cells.

    8. Insight into Structure-Dependent Self-Activation Mechanism in a Confined Nanospace of Core–Shell Nanocomposites (pages 2086–2090)

      Qiang Sun, Wen-Cui Li and An-Hui Lu

      Version of Record online: 27 DEC 2012 | DOI: 10.1002/smll.201202671

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      An unusual hollow core expansion through in situ self-activation in a confined nanospace is observed, which is due to the different physical and chemical properties of the core and shell. The in situ generated gas molecules (e.g., CO2, H2O) preferentially assemble in the hollow core and create immense pressure, which can gasify the formed carbon shells, resulting in substantially increased porosity and a hollow cavity.

    9. Near-Field Plasmonic Functionalization of Light Harvesting Oxide–Oxide Heterojunctions for Efficient Solar Photoelectrochemical Water Splitting: The AuNP/ZnFe2O4/ZnO System (pages 2091–2096)

      Arif Sheikh, Ashish Yengantiwar, Meenal Deo, Sarika Kelkar and Satishchandra Ogale

      Version of Record online: 30 JAN 2013 | DOI: 10.1002/smll.201202140

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      Strong enhancing effect of plasmonic Au nanoparticles on the photoelectrochemical performance of a ZnFe2O4/ZnO heterojunction used as photoanode for water splitting application is demonstrated. The material properties of Au/ZnFe2O4/ZnO complement each other remarkably well in the configuration proposed in terms of their optical, electronic, and catalytic properties.

    10. Graphene Oxide-Based Fluorescent Biosensor for Protein Detection via Terminal Protection of Small-Molecule-Linked DNA (pages 2097–2101)

      Yue He, Xiaojing Xing, Hongwu Tang and Daiwen Pang

      Version of Record online: 30 JAN 2013 | DOI: 10.1002/smll.201202739

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      A fluorescence method for protein detection is developed based on terminal protection of small-molecule-linked DNA by target protein and a graphene oxide-assisted DNA assay strategy. This design results in fluorescence-enhanced detection that is sensitive and selective for the target protein.

  8. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
    9. Frontispiece
    10. Full Papers
    1. You have free access to this content
      Gold Nanodots: In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots (Small 12/2013) (page 2102)

      Chien-Liang Liu, Tzu-Ming Liu, Tsung-Yuan Hsieh, Han-Wen Liu, Yu-Shing Chen, Cheng-Kun Tsai, Hsieh-Chih Chen, Jong-Wei Lin, Ron-Bin Hsu, Tzung-Dau Wang, Chien-Cheng Chen, Chi-Kuang Sun and Pi-Tai Chou

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370071

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      In vivo imaging of insulin metabolism is realized by T.-M. Liu, P.-T. Chou and co-workers using synthesized human insulin–Au nanodots (NDs). Benefiting from its efficient red to near infrared emission, deep tissue subcellular uptake of insulin–Au NDs can be evaluated with a nonlinear optical microscope. On page 2103, insulin-Au NDs permeate into lipid droplets (LDs) of adipocytes, and enlarged ones in type II diabetes mice have a higher adjacent/LD concentration contrast. Human clinical samples show similar trends in patients with diabetes and coronary artery diseas

  9. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Concepts
    7. Frontispiece
    8. Communications
    9. Frontispiece
    10. Full Papers
    1. In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots (pages 2103–2110)

      Chien-Liang Liu, Tzu-Ming Liu, Tsung-Yuan Hsieh, Han-Wen Liu, Yu-Shing Chen, Cheng-Kun Tsai, Hsieh-Chih Chen, Jong-Wei Lin, Ron-Bin Hsu, Tzung-Dau Wang, Chien-Cheng Chen, Chi-Kuang Sun and Pi-Tai Chou

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/smll.201201887

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      Functional human insulin–Au nanodots are synthesized for the in vivo imaging of insulin metabolism. In vivo investigations on mice ear and ex vivo assays on human fat tissues concluded that cells with rich insulin receptors have a higher uptake of administrated insulin. Therefore, human insulin–Au nanodots provide a new approach to explore subcellular insulin metabolism in model animals or patients with metabolic or cardiovascular diseases.

    2. Adaptive Fabrication of a Flexible Electrode by Optically Self-Selected Interfacial Adhesion and Its Application to Highly Transparent and Conductive Film (pages 2111–2118)

      Bongchul Kang, Jinho Yun, Sung-Gaun Kim and Minyang Yang

      Version of Record online: 18 JAN 2013 | DOI: 10.1002/smll.201201485

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      Optically self-selected interfacial adhesion based on metal nano-farming from a particle-free metallic solution is used to fabricate a high-resolution electrode, with performance and quality close to those obtained by vacuum deposition, on a heat-sensitive flexible film. This method could be an alternative to conventional vacuum and printing processes for transparent conductor fabrication.

    3. TGF-β1 Conjugated to Gold Nanoparticles Results in Protein Conformational Changes and Attenuates the Biological Function (pages 2119–2128)

      Yuh-Shyan Tsai, Yu-Hung Chen, Pai-Chiao Cheng, Hsin-Tzu Tsai, Ai-Li Shiau, Tzong-Shin Tzai and Chao-Liang Wu

      Version of Record online: 20 JAN 2013 | DOI: 10.1002/smll.201202755

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      Dysfunction of transforming growth factor-beta 1 (TGF-β1) by gold nanoparticles (AuNPs) attenuates tumor growth due to conformational changes at both the secondary and tertiary structures. In vivo, the amounts of CD4+ and CD8+ T lymphocytes increase and the tumor volume decreases in the presence of AuNPs, which is evidence of immune-response recovery through inhibiting immunosuppressive TGF-β1 signaling.

    4. Polymeric Nanoparticles with Sequential and Multiple FRET Cascade Mechanisms for Multicolor and Multiplexed Imaging (pages 2129–2139)

      Anil Wagh, Faidat Jyoti, Sanku Mallik, Steven Qian, Estelle Leclerc and Benedict Law

      Version of Record online: 29 JAN 2013 | DOI: 10.1002/smll.201202655

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      Polymeric nanoparticles with distinct emission outputs are developed by the encapsulation of two or more complementary organic fluorophores inside an optically inert matrix. Simply by changing the identity, amount, and ratio of the doped fluorophores, the particles with either single or multiple emission signatures are fine-tuned for multicolor and multiplexed imaging applications.

    5. Nanotopographical Cues Augment Mesenchymal Differentiation of Human Embryonic Stem Cells (pages 2140–2151)

      Emmajayne Kingham, Kate White, Nikolaj Gadegaard, Matthew J. Dalby and Richard O. C. Oreffo

      Version of Record online: 30 JAN 2013 | DOI: 10.1002/smll.201202340

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      Nanopits direct mesenchymal differentiation of human embryonic stem cells in the absence of chemical cues. Cells incubated on a near-square arrangement of nanopits show enhanced expression of mesenchymal and stromal cell markers such as STRO-1. Reciprocal expression of E-cadherin and N-cadherin provide evidence of an epithelial-to-mesenchymal transition during nanotopographical differentiation.

    6. Protein–Carbohydrate Complex Reveals Circulating Metastatic Cells in a Microfluidic Assay (pages 2152–2161)

      G. Simone, N. Malara, V. Trunzo, G. Perozziello, P. Neuzil, M. Francardi, L. Roveda, M. Renne, U. Prati, V. Mollace, A. Manz and E. Di Fabrizio

      Version of Record online: 11 FEB 2013 | DOI: 10.1002/smll.201202867

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      A heterogeneous population of cells (tumor and non-tumor cells) seed and come into contact with the substrate, either forming a specific carbohydrate–protein complex or undergoing nonspecific interactions. Only the cells over-expressing galectin-3 and forming specific complex with the substrate are grasped by the microfluidic assay. Multivalency is exploited by a substrate of beads bearing the carbohydrate, permitting an increase in sensitivity of the assay, while specificity is achieved by the equilibrium between the binding and shear forces.

    7. Quantum Dot-Based Thermal Spectroscopy and Imaging of Optically Trapped Microspheres and Single Cells (pages 2162–2170)

      Patricia Haro-González, William T. Ramsay, Laura Martinez Maestro, Blanca del Rosal, Karla Santacruz-Gomez, Maria del Carmen Iglesias-de la Cruz, Francisco Sanz-Rodríguez, Jing Yuang Chooi, Paloma Rodriguez Sevilla, Marco Bettinelli, Debaditya Choudhury, Ajoy K. Kar, José García Solé, Daniel Jaque and Lynn Paterson

      Version of Record online: 11 FEB 2013 | DOI: 10.1002/smll.201201740

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      During optical trapping of living cells, water absorption causes relevant intracellular heating. Quatum dot fluorescence nanothermometry is used here to evaluate the magnitude of this laser-induced heating (that could be larger than 10 °C for moderate trapping powers) as well as to find routes to minimize it by, for example, an adequate selection of the trapping wavelength.

    8. Comparison of Nanotube–Protein Corona Composition in Cell Culture Media (pages 2171–2181)

      Jonathan H. Shannahan, Jared M. Brown, Ran Chen, Pu Chun Ke, Xianyin Lai, Somenath Mitra and Frank A. Witzmann

      Version of Record online: 16 JAN 2013 | DOI: 10.1002/smll.201202243

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      Nanomaterials associating with proteins form a protein corona which may affect their toxicity. Through a novel proteomics approach, this study determines distinct protein corona formations on a variety of carbon-based nanotubes. Protein and nanotube characteristics which may facilitate these interactions are evaluated. The results suggest differential protein corona composition based on functionalization and purity of nanotubes.

    9. Self-Organized Graphene Nanosheets with Corrugated, Ordered Tip Structures for High-Performance Flexible Field Emission (pages 2182–2188)

      Hee Jin Jeong, Hae Deuk Jeong, Ho Young Kim, Seung Yol Jeong, Joong Tark Han and Geon-Woong Lee

      Version of Record online: 18 JAN 2013 | DOI: 10.1002/smll.201202143

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      Self-organized graphene nanosheets with corrugated, ordered tip structures ae fabricated by a straightforward self-assembly method. The size, uniformity of the arrays, and alignment of tips are successfully controlled by the viscosity of the graphene oxide/octadecylamine solution. The vertically aligned tip structures of graphene thin films fabricated on polymeric substrate show excellent field emission characteristics upon bending.

    10. Shape- and Nitric Oxide Flux-Dependent Bactericidal Activity of Nitric Oxide-Releasing Silica Nanorods (pages 2189–2198)

      Yuan Lu, Danielle L. Slomberg, Bin Sun and Mark H. Schoenfisch

      Version of Record online: 30 JAN 2013 | DOI: 10.1002/smll.201201798

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      Nitric oxide (NO)-releasing silica nanorods (SNRs) are synthesized with different aspect ratios and NO-release kinetics. The antibacterial efficacy of the SNRs is evaluated against both Gram–positive and –negative bacteria, and depend on both the particle shape and NO-release kinetics.

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