Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase (pages 2721–2729)
Fernando T. Andón, Alexandr A. Kapralov, Naveena Yanamala, Weihong Feng, Arjang Baygan, Benedict J. Chambers, Kjell Hultenby, Fei Ye, Muhammet S. Toprak, Birgit D. Brandner, Andrea Fornara, Judith Klein-Seetharaman, Gregg P. Kotchey, Alexander Star, Anna A. Shvedova, Bengt Fadeel and Valerian E. Kagan
Article first published online: 27 FEB 2013 | DOI: 10.1002/smll.201202508
Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant-generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.