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6-Gingerol inhibits fungal alpha amylase: Enzyme kinetic and molecular modeling studies

Authors

  • Ignatius Tintu,

    1. Department of Biotechnology and Microbiology, Kannur University, Palayad, Kerala, India
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  • Kalarickal Vijayan Dileep,

    1. Department of Biotechnology and Microbiology, Kannur University, Palayad, Kerala, India
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  • Chandran Remya,

    1. Department of Biotechnology and Microbiology, Kannur University, Palayad, Kerala, India
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  • Anu Augustine,

    1. Department of Biotechnology and Microbiology, Kannur University, Palayad, Kerala, India
    2. Inter-University Centre for Biosciences, Kannur University, Kannur, Kerala, India
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  • Chittalakkottu Sadasivan

    Corresponding author
    1. Department of Biotechnology and Microbiology, Kannur University, Palayad, Kerala, India
    2. Inter-University Centre for Biosciences, Kannur University, Kannur, Kerala, India
    • Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Palayad P O, Kerala – 670 661, India.
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  • Colour online: See the article online to view Figs. 3–5 in colour.

Abstract

Alpha amylases are hydrolytic enzymes that are widespread in nature, being found in animals, microorganisms, and plants. These enzymes hydrolyze starch molecules into reducing sugars. Alpha amylases from microbial sources have several applications in industrial sectors. This enzyme is an effective target for the development of anti-fungal agents. The binding affinity and enzyme inhibitory properties of 6-gingerol toward alpha amylase have been determined. Molecular modeling and docking has been carried out, in order to get the molecular level interactions. Enzyme inhibition studies proved that 6-gingerol is a competitive inhibitor of fungal alpha amylase. It was inferred that 6-gingerol is a potent natural inhibitor of alpha amylase.

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