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Version of Record online: 15 MAY 2012
Copyright © 2012 AlphaMed Press
Volume 30, Issue 6, pages 1152–1162, June 2012
How to Cite
Lemos, D. R., Paylor, B., Chang, C., Sampaio, A., Underhill, T. M. and Rossi, F. M. V. (2012), Functionally Convergent White Adipogenic Progenitors of Different Lineages Participate in a Diffused System Supporting Tissue Regeneration. STEM CELLS, 30: 1152–1162. doi: 10.1002/stem.1082
Author contributions: D.R.L.: conception and design, collection and/or assembly of data, data analysis and interpretation, manuscript writing, and final approval of manuscript; B.P. and C.C.: collection and/or assembly of data, data analysis and interpretation, and final approval of manuscript; A.S.: conception and design, collection and/or assembly of data, data analysis and interpretation, and final approval of manuscript; M.U.: conception and design, data analysis and interpretation, and final approval of manuscript; F.M.V.R.: conception and design, data analysis and interpretation, manuscript writing, financial support, and final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS March 13, 2012.
- Issue online: 15 MAY 2012
- Version of Record online: 15 MAY 2012
- Accepted manuscript online: 13 MAR 2012 02:27PM EST
- Manuscript Accepted: 11 FEB 2012
- Manuscript Received: 16 NOV 2011
- CIHR. Grant Number: MOP-82864
- Heart and Stroke Foundation of Canada
Additional Supporting Information may be found in the online version of this article.
|SC_11-1088_sm_supplFigure1.pdf||89K||Supplementary figure 1. (A) Lin−:α7 −:CD34−:Sca1+:YFP+ cells purified from the cephalic depot were cultured in chondrogenic medium and osteogenic medium. MEFs were used as positive control. Analysis of chondrogenic (upper panel) and osteogenic (lowe panel) gene expression was performed using a custom-designed Taqman Gene Signature array (Applied Biosystems).|
|SC_11-1088_sm_supplFigure2.pdf||98K||Supplementary figure 2. (A) Flow cytometry analysis of the equivalence between Lin−:α7 −:Sca1+ and Lin−:α7 −:PDGFRα+ cells in the cephalic fat and masseter of PDGFRα::H2B-eGFP mice.|
|SC_11-1088_sm_supplFigure3.pdf||67K||Supplementary figure 3. (A) Analysis of plasma insulin and glucose in WT and A-ZIP/F-1 mice, four weeks after injection of 1.75 x105 NC-FAPs or 5x104 M-FAPs. The Sham group received vehicle only. Results are shown as mean ± SEM for each group (n=4)., p, 0.05.|
|SC_11-1088_sm_supplFigure4.pdf||261K||Supplementary figure 4. (A) Lineage composition of the FAP population in the TA of WNT1-Cre/R26-YFP mice at day 3 post NTX damage. Percentages of NC-FAPs are indicated in the histograms. (B) Quantification of the total FAP populations in both the masseter and TA at day 3 post NTX injection shown as percentage of parent population (Lin- cells). Results are shown as mean ± SEM for each group (n=5). , p, 0.05. (C) Imunofluorescence staining for YFP and PDGFRα was used to study masseter infiltration following NTX damage in WNT1-Cre/R26-YFP mice. Representative images of TAs from non-damaged (D0) and day 3 post-NTX injection (D3) mice are shown. Higher magnifications are depicted on the right.|
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