Regenerative Medicine

Xenotransplanted Embryonic Kidney Provides a Niche for Endogenous Mesenchymal Stem Cell Differentiation into Erythropoietin-Producing Tissue†‡

  1. Kei Matsumoto1,2,
  2. Takashi Yokoo1,2,3,§,*,
  3. Hitomi Matsunari3,4,
  4. Satomi Iwai3,5,
  5. Shinya Yokote1,2,
  6. Takumi Teratani6,
  7. Yousof Gheisari1,
  8. Osahiko Tsuji7,
  9. Hideyuki Okano7,
  10. Yasunori Utsunomiya2,
  11. Tatsuo Hosoya2,
  12. Hirotaka James Okano1,7,
  13. Hiroshi Nagashima3,4,
  14. Eiji Kobayashi3,6

Article first published online: 15 MAY 2012

DOI: 10.1002/stem.1101

Issue

STEM CELLS

STEM CELLS

Volume 30, Issue 6, pages 1228–1235, June 2012

Additional Information

How to Cite

Matsumoto, K., Yokoo, T., Matsunari, H., Iwai, S., Yokote, S., Teratani, T., Gheisari, Y., Tsuji, O., Okano, H., Utsunomiya, Y., Hosoya, T., Okano, H. J., Nagashima, H. and Kobayashi, E. (2012), Xenotransplanted Embryonic Kidney Provides a Niche for Endogenous Mesenchymal Stem Cell Differentiation into Erythropoietin-Producing Tissue. STEM CELLS, 30: 1228–1235. doi: 10.1002/stem.1101

Author Information

  1. 1

    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine,The Jikei University School of Medicine, Minato-ku, Tokyo, Japan

  2. 2

    Department Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan

  3. 3

    Meiji University International Institute for Bio-Resource Research, Kawasaki, Kanagawa, Japan

  4. 4

    Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan

  5. 5

    Department of Surgery (I), Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan

  6. 6

    Division of Development of Advanced Treatment, Center for Development of Advanced Medical Technology, Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan

  7. 7

    Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  1. §

    Telephone: +81-3-3433-1111; Fax: +81-3-3433-4297

*Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan

  1. †

    Author contributions: K.M., S.Y., and Y.G.: performed transgenic mice and rat experiments and contributed to manuscript preparation; T.Y.: planned and supervised all experiments and contributed to manuscript preparation; H.M. and H.N.: performed pig embryo experiments and contributed to manuscript preparation; S.I.: performed surgical procedures on cats and contributed to manuscript preparation; T.T.: performed isolation and establishment of mesenchymal stem cells and contributed to manuscript preparation; O.T., J.O., and H.O.: established the E2F1 mouse and contributed to manuscript preparation; Y.U. and T.H.: provided administrative, technical and material support, and contributed to manuscript preparation; E.K.: had full access to all study data, takes responsibility for the integrity of data and the accuracy of data analysis, and contributed to manuscript preparation.

  2. ‡

    Disclosure of potential conflicts of interest is found at the end of this article.

  3. First published online in STEM CELLSEXPRESS April 4, 2012.

  4. §

    Telephone: +81-3-3433-1111; Fax: +81-3-3433-4297

Publication History

  1. Issue published online: 15 MAY 2012
  2. Article first published online: 15 MAY 2012
  3. Accepted manuscript online: 4 APR 2012 08:47AM EST
  4. Manuscript Accepted: 16 MAR 2012
  5. Manuscript Received: 11 NOV 2011

Funded by

  • Baxter Extramural Grant Program
  • Ministry of Education, Culture, Sports, Science and Technology of Japan
  • Otsuka Pharmaceutical Factory, Inc

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