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Additional Supporting Information may be found in the online version of this article.

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SC_12-0245_sm_supplFigure1.pdf122KSupporting Information Figure 1. Localization of recombinant CPP-CARM1 in the nuclei of hMSCs according to protein concentration. The CPP-CARM1 protein (0, 1, 2, 4 μg/ml) was transduced into hMSCs and then detected 24 h after treatment by immunocytochemistry using an anti-6x His-tag antibody. Nuclei were counterstained with DAPI, and the images were merged. The group treated with 2 μg/ml CPP-CARM1 showed the best level of CPP-CARM1 delivery into the nuclei of hMSCs. Scale bars represent 10 μm.
SC_12-0245_sm_supplFigure2.pdf182KSupporting Information Figure 2. Microarray analysis of the expression patterns of all genes in hMSCs with or without treatment with CPP-CARM1 for 48 h. The heat map showing the expression profile of genes up- and down-regulated by greater than 50%, is based on the average of all samples. Green and red indicate decreased and increased expression, respectively.
SC_12-0245_sm_supplFigure3.pdf155KSupporting Information Figure 3. Microarray analysis of expression patterns of adipogenesisrelated genes in hMSCs with or without treatment with CPP-CARM1 for 48 h. The heat map showing the expression profile of genes up- and downregulated by greater than 50% is based on the average of all samples. Green and red indicate decreased and increased expression, respectively.
SC_12-0245_sm_supplFigure4.pdf157KSupporting Information Figure 4. Microarray analysis of expression patterns of osteogenesisrelated genes in hMSCs with or without treatment with CPP-CARM1 for 48 h. The heat map showing the expression profile of genes up- and downregulated by greater than 50% is based on the average of all samples. Green and red indicate decreased and increased expression, respectively.
SC_12-0245_sm_supplFigure5.pdf183KSupporting Information Figure 5. Microarray analysis of expression pattern of myogenesisrelated genes in hMSCs with or without treatment with CPP-CARM1 for 48 h. The heat map showing the expression profile of genes up- and downregulated by greater than 50% is based on the average of all samples. Green and red indicate decreased and increased expression, respectively.
SC_12-0245_sm_supplFigure6.pdf118KSupporting Information Figure 6 Microarray analysis of expression pattern of chondrogenesisrelated genes in hMSCs with or without treatment with CPP-CARM1 for 48 h. The heat map showing the expression profile of genes up- and downregulated by greater than 50% is based on the average of all samples. Green and red indicate decreased and increased expression, respectively.
SC_12-0245_sm_supplTable1.pdf132KSupplementary Table 1

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