Author contributions: Y.C.L.: design of the study, collection, analysis and interpretation of data, and manuscript writing; S.H.T. and Z.Y.Z.: conception and design of the study and analysis and interpretation of data; M.S.K.C.: conception and design of the study, analysis and interpretation of data, and manuscript writing; E.S.M.L. and R.D.K.: analysis and interpretation of data; C.N.Z.M.: analysis and interpretation of data and manuscript writing; N.K.R.: provision of study material; R.J.M.B.: provision of study material and analysis and interpretation of data; N.M.F.: analysis of data and manuscript writing; M.C.: conception and design of the study, administrative support, and analysis of data; J.K.Y.C.: conception and design, financial support, administrative support, provision of study materials, analysis of data, manuscript writing, and final approval of the manuscript.
Article first published online: 20 AUG 2012
Copyright © 2012 AlphaMed Press
Volume 30, Issue 9, pages 1911–1924, September 2012
How to Cite
Liu, Y., Teoh, S.-H., Chong, M. S. K., Lee, E. S. M., Mattar, C. N. Z., Randhawa, N. K., Zhang, Z.-Y., Medina, R. J., Kamm, R. D., Fisk, N. M., Choolani, M. and Chan, J. K. Y. (2012), Vasculogenic and Osteogenesis-Enhancing Potential of Human Umbilical Cord Blood Endothelial Colony-Forming Cells. STEM CELLS, 30: 1911–1924. doi: 10.1002/stem.1164
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS June 3, 2012.
- Issue published online: 20 AUG 2012
- Article first published online: 20 AUG 2012
- Accepted manuscript online: 3 JUL 2012 07:58AM EST
- Manuscript Accepted: 12 JUN 2012
- Manuscript Received: 31 JAN 2012
- National Medical Research Council of Singapore. Grant Numbers: NMRC/1179/2008, NMRC/1268/2010
- NMRC Clinician Scientist Award. Grant Numbers: CSA/007/2009, CSA/012/2009
Additional Supporting Information may be found in the online version of this article.
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|SC-12-0107_sm_Supplfigure1.pdf||297K||Figure S1 - Characterization of UCB-ECFC (A) Phase contrast light microscopy of endothelial progenitor cells demonstrated typical cobblestone morphology of endothelial cells. (B) ECFC differentiated and formed networks when plated on Matrigel ® Immunostaining demonstrated expression of (C) acLDL uptake (red), (D) CD31, (E) von Willebrand Factor, (F) VE Cadherin, indicating endothelial phenotype and function. Cell nuclei were counterstained with Propidium Iodide (red) and DAPI (blue) accordingly.|
|SC-12-0107_sm_Supplfigure2.pdf||368K||Figure S2 - Immunophenotypic characterization of hfMSC using flow cytometry showed high expression of MSC markers such as (A-C) CD73, CD90, CD105 and did not express hematopoietic and endothelial markers such as (D-F) CD14, CD34 and CD45.|
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