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Article first published online: 20 SEP 2012
Copyright © 2012 AlphaMed Press
Volume 30, Issue 10, pages 2221–2233, October 2012
How to Cite
Rodríguez-Jiménez, F. J., Alastrue-Agudo, A., Erceg, S., Stojkovic, M. and Moreno-Manzano, V. (2012), FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction. STEM CELLS, 30: 2221–2233. doi: 10.1002/stem.1189
Author contributions: F.J.R.J., M.S, and V.M.M: Conceived and designed the experiments; V.M.M and M.S.: Financial support to perform the work; F.J.R.J., A.A.A, S.E., and V.M.M: Performed the experiments; F.J.R.J. and V.M.M., Wrote the paper and conceived and designed the experiments.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS August 3, 2012.
- Issue published online: 20 SEP 2012
- Article first published online: 20 SEP 2012
- Accepted manuscript online: 3 AUG 2012 02:24PM EST
- Manuscript Accepted: 22 JUN 2012
- Manuscript Received: 19 APR 2012
Additional Supporting Information may be found in the online version of this article.
|sc-12-0382_sm_SupplFigure1.TIF||61K||Supplementary Figure 1. Semi-quantitative PCR analysis of genes associated with GLUT-4 membrane translocation: Hexokinase II, Snap47 Flot1 and Vamp7. The mean ± SD of four different samples of epSPC treated with FM19G11 (500 nM) or its vehicle (DMSO) for 48 h are represented. Gene expression was normalized to the housekeeping gene 18S.|
|sc-12-0382_sm_SupplFigure2.TIF||99K||Supplementary Figure 2. FM19G11 induces AKT/mTOR and AMPK phosphorylation in human skeletal muscle (hSKM) and white adipocytes (hWAdip) cells. Treatment of FM19G11 (500 nM) induced phosphorylation in a time-response manner in both cell types when compared with non-treated cells. β-actin was used as loading control.|
|sc-12-0382_sm_SupplTable1.TIF||66K||Supplemental Table 1.|
|sc-12-0382_sm_Supplvideo.wmv||2982K||Supplementary Video. Video-based motion analysis for BBB evaluation is shown for a representative animal of the DMSO or FM19G11-treated group four weeks after SCI.|
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