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SC-12-0631_sm_SupplFigure1.pdf35KS1. Analysis of peripheral blood from 8-9 weeks and 21-24 weeks old Ercc1-/Δ mice and littermate controls. Units are WBC, RBC, and number of lymphocytes, monocytes and granulocytes: 103/mm; HGB and MCHC: g/dL; HCT and % lymphocytes, monocytes and granulocytes: percent; MCH: pictograms; MCV and MPV: femtoliters. * indicates statistical difference between genotypes, paired Student's t-test (8-9 weeks-old (n=7): MCV p=0.02; RDW p=0.0002; 21-24 weeks-old (n=5): WBC p=0.01; MCV p=0.003; # lymphocytes p=0.05).
SC-12-0631_sm_SupplFigure2.pdf112KS2. Bone marrow cells from donor mice (CD45.1, B6) were transplanted into lethally irradiated (10 Gy) wild type (Ercc1+/+) recipient mice (B6; FVB, CD45. 1/2). At 9 weeks posttransplantion, the recipients' peripheral blood (PB, upper panels) and bone marrow (BM, lower panels) were analyzed for donor cell contribution. Donor-derived bone marrow cells (CD45.1) in the recipient's bone marrow (n>3/each group) were gated and further analyzed for the frequency of LSK cells (CD45.1, LSK).
SC-12-0631_sm_SupplFigure3.pdf166KS3. LSK cells from 16- (n=3) and 21 week (n=6) old mice of the indicated genotypes were stained with anti-CXCR4 antibody. Upper: Shown are representative flow cytometry data. Numbers represent the percent of cells in each quadrant. Lower: Percentage of CXCR-4 positive LSK cells are shown as mean ± standard deviation (s.d.).

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