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Translational and Clinical Research
Article first published online: 25 FEB 2013
Copyright © 2012 AlphaMed Press
Volume 31, Issue 3, pages 417–422, March 2013
How to Cite
Hynds, R. E. and Giangreco, A. (2013), Concise Review: The Relevance of Human Stem Cell-Derived Organoid Models for Epithelial Translational Medicine. STEM CELLS, 31: 417–422. doi: 10.1002/stem.1290
Author contributions: R.E.H. and A.G.: wrote, edited, and drafted all figures.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSEXPRESS December 3, 2012.
- Issue published online: 25 FEB 2013
- Article first published online: 25 FEB 2013
- Accepted manuscript online: 3 DEC 2012 07:41AM EST
- Manuscript Accepted: 15 NOV 2012
- Manuscript Received: 1 OCT 2012
- BBSRC-CASE studentship with industrial support from Unilever
- European Research Council Starting Investigator Grant
- Stem cell;
- Translational medicine;
- Drug discovery;
- 3D culture;
Epithelial organ remodeling is a major contributing factor to worldwide death and disease, costing healthcare systems billions of dollars every year. Despite this, most fundamental epithelial organ research fails to produce new therapies and mortality rates for epithelial organ diseases remain unacceptably high. In large part, this failure in translating basic epithelial research into clinical therapy is due to a lack of relevance in existing preclinical models. To correct this, new models are required that improve preclinical target identification, pharmacological lead validation, and compound optimization. In this review, we discuss the relevance of human stem cell-derived, three-dimensional organoid models for addressing each of these challenges. We highlight the advantages of stem cell-derived organoid models over existing culture systems, discuss recent advances in epithelial tissue-specific organoids, and present a paradigm for using organoid models in human translational medicine. STEM CELLS2013;31:417–422