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Regenerative Medicine
Brief Report: Long-Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging†‡§
Article first published online: 25 FEB 2013
DOI: 10.1002/stem.1294
Copyright © 2012 AlphaMed Press
Additional Information
How to Cite
Singh, L., Brennan, T. A., Kim, J.-H., Egan, K. P., Mcmillan, E. A., Chen, Q., Hankenson, K. D., Zhang, Y., Emerson, S. G., Johnson, F. B. and Pignolo, R. J. (2013), Brief Report: Long-Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging. STEM CELLS, 31: 607–611. doi: 10.1002/stem.1294
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Author contributions: L.S., T.B., J.-H.K., and Y.Z.: collection and/or assembly of data, data analysis and interpretation, manuscript writing, and final approval of manuscript; K.P.E. and E.A.M.: collection and/or assembly of data and final approval of manuscript; Q.C.: collection and/or assembly of data, provision of study materials, and final approval of manuscript; K.D.H. and S.G.E.: data analysis and interpretation, manuscript writing, and final approval of manuscript; F.B.J.: collection and/or assembly of data, provision of study materials, data analysis and interpretation, manuscript writing, and final approval of manuscript; R.J.P.: conception and design, financial support, collection and/or assembly of data, data analysis and interpretation, manuscript writing, and final approval of manuscript. L.S. and T.A.B. contributed equally to this article.
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Disclosure of potential conflicts of interest is found at the end of this article.
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First published online in STEM CELLSEXPRESS November 29, 2012.
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Telephone: 215-746-8138; Fax: 215-573-2133
Publication History
- Issue published online: 25 FEB 2013
- Article first published online: 25 FEB 2013
- Accepted manuscript online: 29 NOV 2012 05:50AM EST
- Manuscript Accepted: 5 NOV 2012
- Manuscript Revised: 26 OCT 2012
- Manuscript Received: 16 AUG 2012
Funded by
- National Institutes of Health/National Institute. Grant Number: R01AG028873
- University of Pennsylvania Institute
- Penn Center for Musculoskeletal Disorders
- Abstract
- Article
- References
- Supporting Information
- Cited By
Additional Supporting Information may be found in the online version of this article.
| Filename | Format | Size | Description |
|---|---|---|---|
| sc-12-0760_sm_SupplFigure1.pdf | 147K | Figure S1. (A) Adherent MPCs from young wild-type donors are CD45− Sca-1+ cells. Gated cells are shown in the left panel. Cells are > 99.5% CD45− and > 96.5% Sca-1+ (right panel). SSC, side scatter; FSC, forward scatter. (B) Differentiation of GFP+ CD45− Sca-1+ mesenchymal progenitor cells (MPCs) into osteoblasts and adipocytes. Original magnification, 200X. | |
| sc-12-0760_sm_SupplFigure2.pdf | 4401K | Figure S2. Donor MPCs differentiate into bone-lining osteoblasts (and subsequently osteocytes) that are incorporated into bone. Arrowheads indicate representative bone- lining cells. Arrows indicate representative osteocytes in their lacunae. Scale bar = 10 μm. | |
| sc-12-0760_sm_SupplFigure3.pdf | 75K | Figure S3. BMT in Wrn−/−Terc−/− animals preserves bone osteoblasts/bone surface (N. Ob/BS) and number of osteoclasts/bone surface (N. Oc/BS). | |
| sc-12-0760_sm_SupplInform.pdf | 101K | Supplementary Data |
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