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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
sc-12-0760_sm_SupplFigure1.pdf147KFigure S1. (A) Adherent MPCs from young wild-type donors are CD45− Sca-1+ cells. Gated cells are shown in the left panel. Cells are > 99.5% CD45− and > 96.5% Sca-1+ (right panel). SSC, side scatter; FSC, forward scatter. (B) Differentiation of GFP+ CD45− Sca-1+ mesenchymal progenitor cells (MPCs) into osteoblasts and adipocytes. Original magnification, 200X.
sc-12-0760_sm_SupplFigure2.pdf4401KFigure S2. Donor MPCs differentiate into bone-lining osteoblasts (and subsequently osteocytes) that are incorporated into bone. Arrowheads indicate representative bone- lining cells. Arrows indicate representative osteocytes in their lacunae. Scale bar = 10 μm.
sc-12-0760_sm_SupplFigure3.pdf75KFigure S3. BMT in Wrn−/−Terc−/− animals preserves bone osteoblasts/bone surface (N. Ob/BS) and number of osteoclasts/bone surface (N. Oc/BS).
sc-12-0760_sm_SupplInform.pdf101KSupplementary Data

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