• 1
    Piotrowska-Nitsche K, Perea-Gomez A, Haraguchi S et al. Four-cell stage mouse blastomeres have different developmental properties. Development 2005; 132: 479490.
  • 2
    Torres-Padilla ME, Parfitt DE, Kouzarides T et al. Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 2007; 445: 214218.
  • 3
    Niwa H. How is pluripotency determined and maintained? Development 2007; 134: 635646.
  • 4
    Mitsui K, Tokuzawa Y, Itoh H et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113: 631642.
  • 5
    Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113: 643655.
  • 6
    Niwa H, Toyooka Y, Shimosato D et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005; 123: 917929.
  • 7
    Avilion AA, Nicolis SK, Pevny LH et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003; 17: 126140.
  • 8
    Ivanova N, Dobrin R, Lu R et al. Dissecting self-renewal in stem cells with RNA interference. Nature 2006; 442: 533538.
  • 9
    Masui S, Nakatake Y, Toyooka Y et al. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 2007; 9: 625635.
  • 10
    Meshorer E, Yellajoshula D, George E et al. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 2006; 10: 105116.
  • 11
    Kouzarides T. Chromatin modifications and their function. Cell 2007; 128: 693705.
  • 12
    Azuara V, Perry P, Sauer S et al. Chromatin signatures of pluripotent cell lines. Nat Cell Biol 2006; 8: 532538.
  • 13
    Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125: 315326.
  • 14
    Boyer LA, Plath K, Zeitlinger J et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441: 349353.
  • 15
    Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006; 38: 431440.
  • 16
    O'Carroll D, Erhardt S, Pagani M et al. The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol 2001; 21: 43304336.
  • 17
    Lee TI, Jenner RG, Boyer LA et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 2006; 125: 301313.
  • 18
    Yang YH, Dudoit S, Luu P et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 2002; 30: e15.
  • 19
    Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3:Article3.
  • 20
    Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B 1995; 57: 289300.
  • 21
    Loh YH, Zhang W, Chen X et al. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev 2007; 21: 25452557.
  • 22
    Eisen MB, Spellman PT, Brown PO et al. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95: 1486314868.
  • 23
    Boyle EI, Weng S, Gollub J et al. GO::TermFinder—open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 2004; 20: 37103715.
  • 24
    Okumura-Nakanishi S, Saito M, Niwa H et al. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 2005; 280: 53075317.
  • 25
    Chew JL, Loh YH, Zhang W et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 2005; 25: 60316046.
  • 26
    Kuroda T, Tada M, Kubota H et al. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 2005; 25: 24752485.
  • 27
    Rodda DJ, Chew JL, Lim LH et al. Transcriptional regulation of Nanog by OCT4 and SOX2. J Biol Chem 2005; 280: 2473124737.
  • 28
    Sharova LV, Sharov AA, Piao Y et al. Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol 2007; 307: 446459.
  • 29
    Bedford MT. Arginine methylation at a glance. J Cell Sci 2007; 120: 42434246.
  • 30
    Chambers I, Silva J, Colby D et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007; 450: 12301234.
  • 31
    Yadav N, Lee J, Kim J et al. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A 2003; 100: 64646468.
  • 32
    Lee YH, Coonrod SA, Kraus WL et al. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A 2005; 102: 36113616.
  • 33
    Naeem H, Cheng D, Zhao Q et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol 2007; 27: 120134.
  • 34
    Feng Q, Yi P, Wong J et al. Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol 2006; 26: 78467857.
  • 35
    Cheng D, Cote J, Shaaban S et al. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell 2007; 25: 7183.
  • 36
    Li H, Park S, Kilburn B et al. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase J Biol Chem 2002; 277: 4462344630.
  • 37
    Ohkura N, Takahashi M, Yaguchi H et al. Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific manner. J Biol Chem 2005; 280: 2892728935.