Author contributions: S.P.: conception and design, collection and/or assembly of data, data analysis and interpretation, and manuscript writing; R.v.O.: conception and design and manuscript writing; R.P.C.: conception and design, manuscript writing, and final approval of manuscript.
Article first published online: 24 MAR 2013
Copyright © 2013 AlphaMed Press
Volume 31, Issue 4, pages 613–619, April 2013
How to Cite
Pringle, S., Van Os, R. and Coppes, R. P. (2013), Concise Review: Adult Salivary Gland Stem Cells and a Potential Therapy for Xerostomia. STEM CELLS, 31: 613–619. doi: 10.1002/stem.1327
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLS EXPRESS January 17, 2013.
- Issue published online: 24 MAR 2013
- Article first published online: 24 MAR 2013
- Manuscript Accepted: 17 DEC 2012
- Manuscript Received: 17 OCT 2012
- The Netherlands Organisation for Health Research and Development. Grant Number: ZonMW-Grant nr. 11.600.1023
- Dutch government to the Netherlands Institute for Regenerative Medicine
- NIRM. Grant Number: FES0908
- Dutch Cancer Society. Grant Number: RUG2008-4022
- Stem/progenitor cells;
- Cellular therapy
The ability to speak, swallow, masticate, taste food, and maintain a healthy oral cavity is heavily reliant on the presence of saliva, the hugely important effect of which on our everyday lives is often unappreciated. Hyposalivation, frequently experienced by people receiving radiation therapy for head and neck cancers, results in a plethora of symptoms whose combined effect can drastically reduce quality of life. Although artificial lubricants and drugs stimulating residual function are available to ameliorate the consequences of hyposalivation, their effects are at best transient. Such management techniques do not address the source of the problem: a lack of functional saliva-producing acinar cells, resulting from radiation-induced stem cell sterilization. Post-radiotherapy stimulation of cell proliferation only results in improved saliva secretion when part of the tissue has been spared or when the dose to the salivary gland (SG) remains below a certain level. Therefore, stem cell replacement therapy may be a good option to treat radiation-induced hyposalivation. Substantial progress has been made lately in the understanding of cell turnover in the SG, and the recent identification of stem and progenitor cell populations in the SG provides a basis for studies toward development of a stem cell-based therapy for xerostomia. Here, we review the current state of knowledge of SG stem cells and their potential for use in a cell-based therapy that may provide a more durable cure for hyposalivation. STEM CELLS 2013;31:613–619