Telephone: +44 (0)161 275 5182
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Article first published online: 28 MAY 2009
Copyright © 2009 AlphaMed Press
Volume 27, Issue 9, pages 2069–2080, September 2009
How to Cite
Soncin, F., Mohamet, L., Eckardt, D., Ritson, S., Eastham, A. M., Bobola, N., Russell, A., Davies, S., Kemler, R., Merry, C. L.R. and Ward, C. M. (2009), Abrogation of E-Cadherin-Mediated Cell–Cell Contact in Mouse Embryonic Stem Cells Results in Reversible LIF-Independent Self-Renewal. STEM CELLS, 27: 2069–2080. doi: 10.1002/stem.134
Author contributions: F.S.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript; L.M.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing; D.E.: provision of study material; S.R.: conception and design, administrative support, collection and assembly of data; A.E.: collection and assembly of data; N.B.: conception and design, data analysis and interpretation, manuscript writing; A.R.: provision of study material; S.D.: provision of study material; R.K.: provision of study material; C.M.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript; C.M.W.: conception and design, financial support, provision of study material, collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript.
First published online in STEM CELLS EXPRESS May 28, 2009.
- Issue published online: 8 SEP 2009
- Article first published online: 28 MAY 2009
- Accepted manuscript online: 28 MAY 2009 12:00AM EST
- Manuscript Accepted: 7 MAY 2009
- Manuscript Received: 15 JAN 2009
- 1Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 2003; 21: 183–186., , et al.
- 2E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells. Mol Biol Cell 2007; 18: 2838–2851., , et al.
- 3BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003; 115: 281–292., , et al.
- 4TGF beta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005; 132: 1273–1282., , et al.
- 5Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci 2005; 118: 4495–4509., , .
- 6TGF-β signal transduction. Annu Rev Biochem 1998; 67: 753–791..
- 7Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113: 643–655., , et al.
- 8The ground state of embryonic stem cell self-renewal. Nature 2008; 453: 519–523., , et al.
- 9Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007; 448: 191–195., , et al.
- 10New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007; 448: 196–199., , et al.
- 11The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell 2008; 135: 449–461., , et al.
- 12A role for cadherins in tissue formation. Development 1996; 122: 3185–3194., , et al.
- 13Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 2004; 4: 118–132., .
- 14Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 2007; 134: 31–41., , et al.
- 15p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 2006; 125: 957–969., , et al.
- 16Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res 2007; 67: 11254–11262., , et al.
- 17Catenins: Keeping cells from getting their signals crossed. Dev Cell 2006; 11: 601–612., .
- 18Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006; 16: 51–59., , .
- 19Lack of beta-catenin affects mouse development at gastrulation. Development 1995; 121: 3529–3537., , et al.
- 20The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency. J Cell Sci 2003; 116: 4533–4542., , et al.
- 21Use of the cytomegalovirus promoter for transient and stable transgene expression in mouse embryonic stem cells. Methods Mol Biol 2006; 329: 283–294., , .
- 222006., , et al. Compounds and methods for modulating cell adhesion. U.S. Patent Application US2006183884,
- 23Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: Involvement of fibroblast growth factor receptor-mediated signalling. Exp Cell Res 2004; 294: 366–378., , et al.
- 24MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation 2007; 75: 299–307., , et al.
- 25Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004; 10: 55–63., , et al.
- 26Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A 2007; 104: 5668–5673., , et al.
- 27An alpha-E-catenin gene trap mutation defines its function in preimplantation development. Proc Natl Acad Sci U S A 1997; 94: 901–906., , et al.
- 28Expression of Eph receptors and ephrins is differentially regulated by E-cadherin. J Cell Sci 2000; 113: 1793–1802., .
- 29Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development 2006; 133: 2497–2505., , .
- 30Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J Cell Sci 2007; 120: 55–65., , et al.
- 31Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 2006; 9: 261–272., , et al.
- 32Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006; 66: 8319–8326., .