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Keywords:

  • Cell-based therapy;
  • Middle cerebral artery occlusion;
  • Rat model;
  • Human stem/progenitor cells;
  • Ischemic stroke

Abstract

Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research. STEM Cells 2013;31:1040–1043