Telephone: +61 8 8222 6740 (Office), +61 4 1692 8658 (Mobile); Fax: +61 8 8222 6042
Article first published online: 22 MAY 2013
Copyright © 2013 AlphaMed Press
Volume 31, Issue 6, pages 1040–1043, June 2013
How to Cite
Leong, W. K., Lewis, M. D. and Koblar, S. A. (2013), Concise Review: Preclinical Studies on Human Cell-Based Therapy in Rodent Ischemic Stroke Models: Where Are We Now after a Decade?. STEM CELLS, 31: 1040–1043. doi: 10.1002/stem.1348
Author contributions: W.K.L.: conception and design, collection and assembly of data, data analysis and interpretation, and manuscript writing; M.L.: conception and design, financial support, manuscript writing, and final approval of manuscript; S.K.: conception and design, financial support, data analysis and interpretation, manuscript writing, and final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
first published online in STEM CELLS EXPRESS February 6, 2013.
- Issue published online: 22 MAY 2013
- Article first published online: 22 MAY 2013
- Accepted manuscript online: 6 FEB 2013 11:26PM EST
- Manuscript Accepted: 15 JAN 2013
- Manuscript Received: 28 AUG 2012
- University of Adelaide and the Australian Government
- Cell-based therapy;
- Middle cerebral artery occlusion;
- Rat model;
- Human stem/progenitor cells;
- Ischemic stroke
Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research. STEM Cells 2013;31:1040–1043