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Tissue-Specific Stem Cells
Article first published online: 22 MAY 2013
Copyright © 2013 AlphaMed Press
Volume 31, Issue 6, pages 1044–1050, June 2013
How to Cite
Smith, J. N. P. and Calvi, L. M. (2013), Concise Review: Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells. STEM CELLS, 31: 1044–1050. doi: 10.1002/stem.1370
Author contributions: Laura M. Calvi: conception and design, financial support, administrative support, manuscript writing and final approval of manuscript. Julianne N.P. Smith: conception and design, manuscript writing and final approval of manuscript.
DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST IS FOUND AT THE END OF THIS ARTICLE.
first published online in STEM CELLS EXPRESS February 4, 2013.
- Issue published online: 22 MAY 2013
- Article first published online: 22 MAY 2013
- Accepted manuscript online: 18 MAR 2013 06:54AM EST
- Manuscript Accepted: 29 JAN 2013
- Manuscript Received: 17 SEP 2012
- NIH/NIDDK. Grant Numbers: DK076876, DK081843
- Adult hematopoietic stem cells;
- Bone marrow;
- Bone marrow stromal cells;
- Hemopoietic stem cells;
- Stem cell microenvironment interactions;
- Endothelial cell
Hematopoietic stem cell (HSC) behavior is governed in large part by interactions of the blood system with the bone microenvironment. Increasing evidence demonstrates the profound role the local HSC microenvironment or niche plays in normal stem cell function, in therapeutic activation and in the setting of malignancy. A number of cellular and molecular components of the microenvironment have been identified thus far, several of which are likely to provide exciting therapeutic targets in the near future. Clinically effective strategies for niche manipulation, however, require careful study of the interaction of these niche components. Some of the key findings defining these regulatory interactions are explored in this concise review, with special emphasis on potential translational applications. STEM Cells 2013;31:1044–1050