Telephone: 212-241-7425; Fax: 1-212-241-3518
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Article first published online: 5 JUL 2013
Copyright © 2013 AlphaMed Press
Volume 31, Issue 7, pages 1227–1236, July 2013
How to Cite
Saunders, A., Faiola, F. and Wang, J. (2013), Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor Nanog. STEM CELLS, 31: 1227–1236. doi: 10.1002/stem.1384
Author contributions: A.S.: design and manuscript writing; F.F.: manuscript writing; J.W.: conception and design, financial support, and final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
first published online in STEM CELLS EXPRESS May 7, 2013.
- Issue published online: 5 JUL 2013
- Article first published online: 5 JUL 2013
- Accepted manuscript online: 7 MAY 2013 06:30AM EST
- Manuscript Accepted: 4 MAR 2013
- Manuscript Received: 17 JAN 2013
- NIH. Grant Number: 1R01-GM095942-01A1
- NY state Department of Health. Grant Number: NYSTEM#C026420
- Black Family Stem Cell Institute
- Embryonic stem cells;
- Induced pluripotent stem cells;
Pluripotent embryonic stem cells and induced pluripotent stem cells hold great promise for future use in tissue replacement therapies due to their ability to self-renew indefinitely and to differentiate into all adult cell types. Harnessing this therapeutic potential efficiently requires a much deeper understanding of the molecular processes at work within the pluripotency network. The transcription factors Nanog, Oct4, and Sox2 reside at the core of this network, where they interact and regulate their own expression as well as that of numerous other pluripotency factors. Of these core factors, Nanog is critical for blocking the differentiation of pluripotent cells, and more importantly, for establishing the pluripotent ground state during somatic cell reprogramming. Both mouse and human Nanog are able to form dimers in vivo, allowing them to preferentially interact with certain factors and perform unique functions. Recent studies have identified an evolutionary functional conservation among vertebrate Nanog orthologs from chick, zebrafish, and the axolotl salamander, adding an additional layer of complexity to Nanog function. Here, we present a detailed overview of published work focusing on Nanog structure, function, dimerization, and regulation at the genetic and post-translational levels with regard to the establishment and maintenance of pluripotency. The full spectrum of Nanog function in pluripotent stem cells and in cancer is only beginning to be revealed. We therefore use this evidence to advocate for more comprehensive analysis of Nanog in the context of disease, development, and regeneration. STEM Cells2013;31:1227–1236