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Embryonic Stem Cells/Induced Pluripotent Stem Cells
Article first published online: 5 JUL 2013
Copyright © 2013 AlphaMed Press
Volume 31, Issue 7, pages 1298–1308, July 2013
How to Cite
Folmes, C. D.L., Martinez-Fernandez, A., Perales-Clemente, E., Li, X., Mcdonald, A., Oglesbee, D., Hrstka, S. C., Perez-Terzic, C., Terzic, A. and Nelson, T. J. (2013), Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS. STEM CELLS, 31: 1298–1308. doi: 10.1002/stem.1389
Author contributions: A.M.-F., C.D.L.F., and E.P.-C.: conception and design, collection and/or assembly of data, data analysis and interpretation, manuscript writing; C.P.-T., S.H., and A.M.: collection and/or assembly of data; X.L.: data analysis and interpretation; D.O.: provision of study materials or patients; A.T. and T.J.N.: conception and design, data analysis and interpretation, manuscript writing, final approval of manuscript. C.D.L.F., A.M.-F., and E.P.-C. contributed equally to this article.
Disclosure of potential conflicts of interest is found at the end of this article.
first published online in STEM CELLS EXPRESS April 3, 2013.
- Issue published online: 5 JUL 2013
- Article first published online: 5 JUL 2013
- Accepted manuscript online: 3 APR 2013 05:24AM EST
- Manuscript Accepted: 6 MAR 2013
- Manuscript Received: 17 OCT 2012
- Canadian Institutes of Health Research Fellowship
- Mayo Clinic Center for Regenerative Medicine Fellowship
- Marriott Individualized Medicine Career Development Award
- American Heart Association Midwest Affiliate Postdoctoral Fellowship. Grant Number: AHA 11POST7600085
- Spanish Ministry of Education MEC
- Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome
- NIH New Innovator. Grant Number: OD007015-01
- Marriott Heart Disease Research Program and the Leducq Foundation
Additional Supporting Information may be found in the online version of this article.
|sc-12-0940_sm_SupplFigure1.tif||2723K||Supplemental Figure 1. Homogeneous distribution of heteroplasmy in subclones from iPS cell lines. Individual subclones were isolated, expanded, and profiled for heteroplasmy at position G13513A from the parental M–iPS1 that was originally at passage 13. All clones maintained heteroplasmy between 25% and 60% with the original clone containing 35%.|
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