• 1
    Morrison SJ, Weissman IL. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1994; 1: 661673.
  • 2
    Sharma Y, Astle CM, Harrison DE. Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol 2007; 35: 214220.
  • 3
    Nocka K, Majumder S, Chabot B et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice—evidence for an impaired c-kit kinase in mutant mice. Genes Dev 1989; 3: 816826.
  • 4
    Besmer P. The kit ligand encoded at the murine Steel locus: A pleiotropic growth and differentiation factor. Curr Opin Cell Biol 1991; 3: 939946.
  • 5
    Russell ES. Hereditary anemias of the mouse: A review for geneticists. Adv Genet 1979; 20: 357459.
  • 6
    Nocka K, Buck J, Levi E et al. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J 1990; 9: 32873294.
  • 7
    Muta K, Krantz SB, Bondurant MC et al. Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation. Blood 1995; 86: 572580.
  • 8
    Besmer P. Kit-ligand-stem cell factor. New York, NY: Marcel Dekker, 1997: 369403.
  • 9
    Gerbaulet A, Wickenhauser C, Scholten J et al. Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood 2011; 117: 20122021.
  • 10
    Sommer G, Agosti V, Ehlers I et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci USA 2003; 100: 67066711.
  • 11
    Bosbach B, Deshpande S, Rossi F et al. Imatinib resistance and microcytic erythrocytosis in a KitV558ΔT669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci USA 2012; 109: E22762283.
  • 12
    Liu Y, Pop R, Sadegh C et al. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 2006; 108: 123133.
  • 13
    Challen GA, Boles N, Lin KK et al. Mouse hematopoietic stem cell identification and analysis. Cytometry A 2009; 75: 1424.
  • 14
    Amrani YM, Gill J, Matevossian A et al. The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med 2011; 208: 17571765.
  • 15
    Harrison DE, Jordan CT, Zhong RK et al. Primitive hemopoietic stem cells: Direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol 1993; 21: 206219.
  • 16
    Morita Y, Iseki A, Okamura S et al. Functional characterization of hematopoietic stem cells in the spleen. Exp Hematol 2011; 39: 351-359. e353.
  • 17
    Mo JR, Mathur A, Angagaw M et al. Splenectomy normalizes hematocrit in murine polycythemia vera. PLoS One 2009; 4: e7286.
  • 18
    Akashi K, Traver D, Miyamoto T et al. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193197.
  • 19
    Na Nakorn T, Traver D, Weissman IL et al. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J Clin Invest 2002; 109: 15791585.
  • 20
    Czechowicz A, Kraft D, Weissman IL et al. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 2007; 318: 12961299.
  • 21
    Bowie MB, Kent DG, Copley MR et al. Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood 2007; 109: 50435048.
  • 22
    Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA 1992; 89: 15021506.
  • 23
    McKinney-Freeman SL, Naveiras O, Yates F et al. Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood 2009; 114: 268278.
  • 24
    Ogawa M, Tajima F, Ito T et al. CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations. Ann N Y Acad Sci 2001; 938: 139145.
  • 25
    Agosti V, Karur V, Sathyanarayana P et al. A KIT juxtamembrane PY567-directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol 2009; 37: 159171.
  • 26
    Randall TD, Weissman IL. Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Blood 1997; 89: 35963606.
  • 27
    Nemeth MJ, Kirby MR, Bodine DM. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci USA 2006; 103: 1378313788.
  • 28
    Vogel J, Kiessling I, Heinicke K et al. Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood 2003; 102: 22782284.
  • 29
    Garcia-Montero AC, Jara-Acevedo M, Teodosio C et al. KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: A prospective study of the Spanish network on mastocytosis (REMA) in a series of 113 patients. Blood 2006; 108: 23662372.
  • 30
    Akada H, Yan D, Zou H et al. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood 2010; 115: 35893597.
  • 31
    Mullally A, Lane SW, Ball B et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 2010; 17: 584596.
  • 32
    Agosti V, Corbacioglu S, Ehlers I et al. Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development. J Exp Med 2004; 199: 867878.
  • 33
    Walkley CR, Shea JM, Sims NA et al. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 2007; 129: 10811095.
  • 34
    Thoren LA, Liuba K, Bryder D et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol 2008; 180: 20452053.
  • 35
    Miller CL, Rebel VI, Lemieux ME et al. Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells. Exp Hematol 1996; 24: 185194.
  • 36
    Miller CL, Rebel VI, Helgason CD et al. Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo. Blood 1997; 89: 12141223.
  • 37
    Lerner C, Harrison DE. 5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation. Exp Hematol 1990; 18: 114118.