Concise Review: Sowing the Seeds of a Fruitful Harvest: Hematopoietic Stem Cell Mobilization

Authors

  • Jonathan Hoggatt,

    Corresponding author
    1. Harvard University, Department of Stem Cell and Regenerative Biology, Massachusetts General Hospital, Center for Regenerative Medicine, Harvard Stem Cell Institute, Boston, Massachusetts, USA
    • Correspondence: Louis M. Pelus, Ph.D., Department of Microbiology & Immunology, Indiana University School of Medicine, 950 West Walnut Street, R2-302, Indianapolis, Indiana 46202, USA. Telephone: +1-317-274-7565; Fax: +1-317-274-7592; e-mail: lpelus@iupui.edu; or Jonathan Hoggatt, Ph.D., Harvard University, Department of Stem Cell and Regenerative Medicine/Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN 4400, Boston, Massachusetts 02114, USA. Telephone: +1-617-726-5615; Fax: +1-617-724-2662; e-mail: Hoggatt.Jonathan@mgh.harvard.edu

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  • Jennifer M. Speth,

    1. Indiana University School of Medicine, Department of Microbiology and Immunology, Indianapolis, Indiana, USA
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  • Louis M. Pelus

    Corresponding author
    1. Indiana University School of Medicine, Department of Microbiology and Immunology, Indianapolis, Indiana, USA
    • Correspondence: Louis M. Pelus, Ph.D., Department of Microbiology & Immunology, Indiana University School of Medicine, 950 West Walnut Street, R2-302, Indianapolis, Indiana 46202, USA. Telephone: +1-317-274-7565; Fax: +1-317-274-7592; e-mail: lpelus@iupui.edu; or Jonathan Hoggatt, Ph.D., Harvard University, Department of Stem Cell and Regenerative Medicine/Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN 4400, Boston, Massachusetts 02114, USA. Telephone: +1-617-726-5615; Fax: +1-617-724-2662; e-mail: Hoggatt.Jonathan@mgh.harvard.edu

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  • Author contributions: J.H.: conception and design, collection and/or assembly of data, manuscript writing, and final approval of manuscript; J.M.S.: collection and/or assembly of data and final approval of manuscript; L.M.P.: conception and design, collection and/or assembly of data, manuscript writing, and final approval of manuscript.

Abstract

Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies. Stem Cells 2013;31:2599–2606

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