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Keywords:

  • Hematopoietic stem cell;
  • Mobilization;
  • Granulocyte-colony stimulating factor;
  • CXCR4;
  • Stem cell niche;
  • AMD3100 (plerixafor)

Abstract

Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies. Stem Cells 2013;31:2599–2606