• 1
    Ogden C, Kit B, Flegal K. Prevalence of obesity in the Unites States. NCHS Data Brief 2012;82:18.
  • 2
    Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881887.
  • 3
    Prevention CfDCa. US National diabetes fact sheet: National estimates, general information on diabetes, prediabetes in the Unites States. Atlanta: US Department of Health, Human Services CfDCaP, 2011.
  • 4
    Virtanen KA, Lidell ME, Orava J et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:15181525.
  • 5
    Cypess AM, Lehman S, Williams G et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:15091517.
  • 6
    Cypess AM, White AP, Vernochet C et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013;19:635639.
  • 7
    Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984;64:164.
  • 8
    Ouellet V, Labbe SM, Blondin DP et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012;122:545552.
  • 9
    Lidell ME, Enerback S. Brown adipose tissue—A new role in humans? Nat Rev Endocrinol 2010;6:319325.
  • 10
    Castillo-Quan JI. From white to brown fat through the PGC-1α-dependent myokine irisin: Implications for diabetes and obesity. Dis Model Mech 2012;5:293295.
  • 11
    Baglioni S, Francalanci M, Squecco R et al. Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue. Faseb J 2009;23:34943505.
  • 12
    Mizuno H. Adipose-derived stem and stromal cells for cell-based therapy: Current status of preclinical studies and clinical trials. Curr Opin Mol Ther 2010;12:442449.
  • 13
    Fuller SA, Takahashi M, Hurrell JG. Cloning of hybridoma cell lines by limiting dilution. Curr Protoc Mol Biol 2001;Chapter 11:Unit11 18.
  • 14
    Cristofalo VJ, Allen RG, Pignolo RJ et al. Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation. Proc Natl Acad Sci USA 1998;95:1061410619.
  • 15
    Bostrom P, Wu J, Jedrychowski MP et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463468.
  • 16
    Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293:E444E452.
  • 17
    Heaton JM. The distribution of brown adipose tissue in the human. J Anat 1972;112:3539.
  • 18
    Wu J, Bostrom P, Sparks LM et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366376.
  • 19
    Israels SJ, McMillan-Ward EM. Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. Thromb Res 2010;125:152158.
  • 20
    Kim YJ, Yu JM, Joo HJ et al. Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. Pflugers Arch 2007;455:283296.
  • 21
    Liu TM, Martina M, Hutmacher DW et al. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007;25:750760.
  • 22
    Muraglia A, Corsi A, Riminucci M et al. Formation of a chondro-osseous rudiment in micromass cultures of human bone-marrow stromal cells. J Cell Sci 2003;116:29492955.
  • 23
    Patel AN, Yockman J, Vargas V et al. Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery. Cell Transplant 2013;22:507511.
  • 24
    Lee P, Greenfield JR, Ho KK et al. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2010;299:E601E606.
  • 25
    Gunawardana SC. Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat. Adipocyte 2012;1:250255.
  • 26
    Stanford KI, Middelbeek RJ, Townsend KL et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123:215223.
  • 27
    Lidell ME, Betz MJ, Dahlqvist Leinhard O et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013;19:631634.
  • 28
    Moitra J, Mason MM, Olive M et al. Life without white fat: A transgenic mouse. Genes Dev 1998;12:31683181.
  • 29
    Ho AD, Wagner W, Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy 2008;10:320330.
  • 30
    Kern S, Eichler H, Stoeve J et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:12941301.
  • 31
    Covas DT, Panepucci RA, Fontes AM et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol 2008;36:642654.
  • 32
    Gunawardana SC, Piston DW. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 2012;61:674682.
  • 33
    Christian M, Parker MG. The engineering of brown fat. J Mol Cell Biol 2010;2:2325.
  • 34
    Nechad M, Kuusela P, Carneheim C et al. Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture. Exp Cell Res 1983;149:105118.